2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Anti-infection
  3. HSP Bacterial Antibiotic
  4. Questiomycin A

Questiomycin A  (Synonyms: Phx-3)

目录号: HY-N8439
产品使用指南

摩尔计算器

Questiomycin A (Phx-3) 是一种 GRP78 (细胞保护性内质网伴侣蛋白) 降解剂，能增强 Sorafenib 的抗癌活性。Questiomycin A 也是一种抗菌剂/抗生素，可从 Pseudomonas chlororaphis HT66的代谢物中获得。Questiomycin A 可用癌症以及植物病害生物防治的研究。

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Questiomycin A Chemical Structure

Questiomycin A Chemical Structure

CAS No. : 1916-59-2

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Questiomycin A 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases[1][2].

IC50 & Target

GRP78, bacterial[1][2].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
2 μM
Compound: 1
Compound concentration required to reduce the cell proliferation of human acute T-lymphoblastic leukemia CCRF-CEM cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of human acute T-lymphoblastic leukemia CCRF-CEM cells by 50%, using MTT method
[PMID: 12431048]
CCRF-SB IC50
1 μM
Compound: 1
Compound concentration required to reduce the cell proliferation of human acute B-lymphoblastic leukemia CCRF-SB cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of human acute B-lymphoblastic leukemia CCRF-SB cells by 50%, using MTT method
[PMID: 12431048]
HeLa IC50
2.7 μM
Compound: 1
Compound concentration required to reduce the cell proliferation of cervix carcinoma Hela cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of cervix carcinoma Hela cells by 50%, using MTT method
[PMID: 12431048]
HEp-2 IC50
1.8 μM
Compound: 1
Compound concentration required to reduce the cell proliferation of larynx carcinoma cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of larynx carcinoma cells by 50%, using MTT method
[PMID: 12431048]
体外研究
(In Vitro)

Questiomycin A (3 µM; 24 h) 在 HepG2 细胞中，诱导细胞死亡并下调 GRP78 蛋白的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Questiomycin A 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 3 µM
Incubation Time: 24 h
Result: Suppressed more than 50% of the GRP78 expression and induced cell death.
体内研究
(In Vivo)

Questiomycin A (10 mg/kg; i.p.; once a day for 8 days) 在小鼠模型中，通过降解 GRP78 蛋白以增强 Sorafenib 的抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (HepG2 cells xenograft model)[1].
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; once a day; 8 days.
Result: Stimulated Sorafenib-dependent antitumor activity.
分子量

212.20

Formula

C12H8N2O2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Questiomycin A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Questiomycin A1916-59-2Phx-3Phx3Phx 3HSPBacterialAntibioticHeat shock proteinsHCCcancertumorbacteriaPseudomonas chlororaphisHepG2Hep3BU2OSHuH-7infectionInhibitorinhibitorinhibit

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