2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Anti-infection
  3. HSP Bacterial Antibiotic
  4. Questiomycin A

Questiomycin A  (Synonyms: Phx-3)

目录号: HY-N8439 纯度: 98.20%
COA 产品使用指南 技术支持

Questiomycin A (Phx-3) 是一种 GRP78 (细胞保护性内质网伴侣蛋白) 降解剂，能增强 Sorafenib 的抗癌活性。Questiomycin A 也是一种抗菌剂/抗生素，可从 Pseudomonas chlororaphis HT66的代谢物中获得。Questiomycin A 可用癌症以及植物病害生物防治的研究。

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Questiomycin A Chemical Structure

Questiomycin A Chemical Structure

CAS No. : 1916-59-2

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5 mg ￥400
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10 mg ￥650
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Customer Review

Questiomycin A 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases[1][2].

IC50 & Target

GRP78, bacterial[1][2].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
2 μM
Compound: 1
Compound concentration required to reduce the cell proliferation of human acute T-lymphoblastic leukemia CCRF-CEM cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of human acute T-lymphoblastic leukemia CCRF-CEM cells by 50%, using MTT method
[PMID: 12431048]
CCRF-SB IC50
1 μM
Compound: 1
Compound concentration required to reduce the cell proliferation of human acute B-lymphoblastic leukemia CCRF-SB cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of human acute B-lymphoblastic leukemia CCRF-SB cells by 50%, using MTT method
[PMID: 12431048]
HeLa IC50
2.7 μM
Compound: 1
Compound concentration required to reduce the cell proliferation of cervix carcinoma Hela cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of cervix carcinoma Hela cells by 50%, using MTT method
[PMID: 12431048]
HEp-2 IC50
1.8 μM
Compound: 1
Compound concentration required to reduce the cell proliferation of larynx carcinoma cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of larynx carcinoma cells by 50%, using MTT method
[PMID: 12431048]
体外研究
(In Vitro)

Questiomycin A (3 µM; 24 h) 在 HepG2 细胞中，诱导细胞死亡并下调 GRP78 蛋白的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Questiomycin A 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 3 µM
Incubation Time: 24 h
Result: Suppressed more than 50% of the GRP78 expression and induced cell death.
体内研究
(In Vivo)

Questiomycin A (10 mg/kg; i.p.; once a day for 8 days) 在小鼠模型中，通过降解 GRP78 蛋白以增强 Sorafenib 的抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (HepG2 cells xenograft model)[1].
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; once a day; 8 days.
Result: Stimulated Sorafenib-dependent antitumor activity.
分子量

212.20

Formula

C12H8N2O2
CAS 号
性状

固体

颜色

Brown to black

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 12.5 mg/mL (58.91 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.7125 mL 23.5627 mL 47.1254 mL
5 mM 0.9425 mL 4.7125 mL 9.4251 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Questiomycin A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7125 mL 23.5627 mL 47.1254 mL 117.8134 mL
5 mM 0.9425 mL 4.7125 mL 9.4251 mL 23.5627 mL
10 mM 0.4713 mL 2.3563 mL 4.7125 mL 11.7813 mL
15 mM 0.3142 mL 1.5708 mL 3.1417 mL 7.8542 mL
20 mM 0.2356 mL 1.1781 mL 2.3563 mL 5.8907 mL
25 mM 0.1885 mL 0.9425 mL 1.8850 mL 4.7125 mL
30 mM 0.1571 mL 0.7854 mL 1.5708 mL 3.9271 mL
40 mM 0.1178 mL 0.5891 mL 1.1781 mL 2.9453 mL
50 mM 0.0943 mL 0.4713 mL 0.9425 mL 2.3563 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Questiomycin A1916-59-2Phx-3Phx3Phx 3HSPBacterialAntibioticHeat shock proteinsHCCcancertumorbacteriaPseudomonas chlororaphisHepG2Hep3BU2OSHuH-7infectionInhibitorinhibitorinhibit

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