2. GPCR/G Protein Neuronal Signaling Others
  3. Dopamine Receptor 5-HT Receptor Isotope-Labeled Compounds
  4. Quetiapine-d4-1 fumarate

Quetiapine-d4-1 fumarate  (Synonyms: 富马酸喹硫平-d4)

目录号: HY-B0031S5
产品使用指南

摩尔计算器

Quetiapine-d4-1 fumarate 是氘代标记的 Quetiapine (hemifumarate) (HY-B0031)。Quetiapine hemifumarate 是一种 5-HT 受体激动剂，对人 5-HT1A 的 pEC50 值为 4.77。Quetiapine hemifumarate 是多巴胺受体 (dopamine receptor) 拮抗剂，对人 D2 的 pIC50 值为 6.33。Quetiapine hemifumarate 对人 D2，HT1A，5-HT2A，5-HT2C 受体具有中高等亲和力，pKi 值为 7.25，5.74，7.54，5.55。具有抗抑郁和抗焦虑作用。

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Quetiapine-d<sub>4</sub>-1 fumarate Chemical Structure

Quetiapine-d4-1 fumarate Chemical Structure

CAS No. : 2820085-77-4

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Quetiapine-d4-1 fumarate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Quetiapine-d4-1 fumarate is deuterated labeled Quetiapine (hemifumarate) (HY-B0031). Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quetiapine-d4-1 fumarate 相关抗体:
体内研究
(In Vivo)

Quetiapine (10?mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ)-induced chronic mouse model of demyelination[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

445.57

Formula

C21H21D4N3O2S.1/2C4H4O4
CAS 号
非标记 CAS

111974-72-2
中文名称

富马酸喹硫平杂质42-d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Quetiapine-d4-1 fumarate 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quetiapine-d4-12820085-77-4富马酸喹硫平杂质42-d4Dopamine Receptor5-HT ReceptorIsotope-Labeled CompoundsSerotonin Receptor5-hydroxytryptamine Receptor5-HT1AD25-HT2A5-HT2CAntidepressantanxiolyticInhibitorinhibitorinhibit

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