2. Anti-infection Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Apoptosis
  3. Parasite Potassium Channel Cytochrome P450 Apoptosis
  4. Quinidine gluconic acid

Quinidine gluconic acid  (Synonyms: 奎尼丁葡萄糖酸)

目录号: HY-B1751F
产品使用指南

摩尔计算器

Quinate 是一种抗心律失常剂。Quinate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也是 K+ 通道 (K+ channel) 的有效阻断剂，其 IC50 值为 19.9 μM，也可诱导凋亡。Quinate 也可用作疟疾的研究。

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Quinidine gluconic acid Chemical Structure

Quinidine gluconic acid Chemical Structure

CAS No. : 7054-25-3

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Quinidine gluconic acid 的其他形式现货产品:

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Other Forms of Quinidine gluconic acid:

Quinidine gluconic acid 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Quinate is an antiarrhythmic agent. Quinate is a potent, orally active, selective cytochrome P450db inhibitor. Quinate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinate can be used for malaria research[1][2][3][4].

IC50 & Target

Plasmodium

 

体外研究
(In Vitro)

Quinate shows cytotoxicity against MES-SA cells, and induces apoptosis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quinidine gluconic acid 相关抗体:

Cell Cytotoxicity Assay[4]

Cell Line: MES-SA and MESSA/DX5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.

Apoptosis Analysis[4]

Cell Line: MES-SA and MESSA/DX5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.
体内研究
(In Vivo)

Quinate shows effects on the PTZ-induced seizure threshold[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5]
Dosage: 10, 20, and 30 mg/kg
Administration: Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result: Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
分子量

520.57

Formula

C26H36N2O9
CAS 号
中文名称

奎尼丁葡萄糖酸；异奎宁葡萄糖酸；奎尼定葡萄糖酸；喹啉丁葡萄糖酸；奎纳定葡萄糖酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Quinidine gluconic acid 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinidine7054-25-3奎尼丁葡萄糖酸异奎宁葡萄糖酸奎尼定葡萄糖酸喹啉丁葡萄糖酸奎纳定葡萄糖酸ParasitePotassium ChannelCytochrome P450ApoptosisKcsACYPsoral activitymalariaMES-SAMESSA/DX5Inhibitorinhibitorinhibit

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