2. Anti-infection Membrane Transporter/Ion Channel
  3. Dengue virus Flavivirus Parasite Potassium Channel
  4. Quinine dihydrochloride

Quinine dihydrochloride  (Synonyms: 二盐酸奎宁)

目录号: HY-D0143A
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摩尔计算器

Quinine dihydrochloride 是一种从金鸡纳树皮中提取的生物碱，具有口服活性，可用作抗疟疾研究。Quinine dihydrochloride 是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其 IC50 值为 169 μM。

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Quinine dihydrochloride Chemical Structure

Quinine dihydrochloride Chemical Structure

CAS No. : 60-93-5

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Quinine dihydrochloride 的其他形式现货产品:

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Quinine dihydrochloride 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].

IC50 & Target

Plasmodium

 

体外研究
(In Vitro)

Quinine dihydrochloride (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line[1].
Quinine dihydrochloride (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quinine dihydrochloride 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Human hepatocarcinoma cell line(HepG2)
Concentration: 150 μM
Incubation Time: 30 min
Result: Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.
体内研究
(In Vivo)

Quinine dihydrochloride (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice[2].
Quinine dihydrochloride (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice 7-8-weeks (weighing 24 g)[2]
Dosage: 12 mg/kg, 15 mg/kg
Administration: Oral gavage; every week; 16 weeks
Result: Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
Clinical Trial
分子量

397.34

Formula

C20H26Cl2N2O2
CAS 号
中文名称

二盐酸奎宁； 奎宁二盐酸盐
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Quinine dihydrochloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinine60-93-5二盐酸奎宁 奎宁二盐酸盐Dengue virusFlavivirusParasitePotassium ChannelDENVKcsAanti-malarialcinchonaineInhibitorinhibitorinhibit

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