C-Reactive 蛋白, Human (HEK293)

C-Reactive Protein, an acute-phase protein, is a marker of inflammatory cytokines that assists in complement binding and phagocytosis by macrophages, originated from the liver. C-Reactive Protein is also the first pattern recognition receptor (PRR) to be identified. C-Reactive Protein is significantly associated with the risk of having a first ischemic stroke, especially for small-vessel disease. C-Reactive Protein (Human) is a recombinant protein with tag free that consists of 224 amino acids and is expressed in HEK293^{[1][2][3][4][5][6][7][8][9][10][11]}.

C-Reactive 蛋白 (Human) 是一种环状 (环形) 五聚体蛋白，存在于血浆中，其循环浓度会因炎症而升高。C-Reactive 蛋白 (Human)与死细胞或衰亡细胞表面表达的溶血磷脂酰胆碱（以及某些类型的细菌）结合，以通过结合 C1q 激活经典补体途径^[2]。
C-Reactive 蛋白 (Human) 是由肝脏合成的，响应巨噬细胞，T 细胞和脂肪细胞释放的因子，它是五聚素家族蛋白的一员，含有信号肽^[3]。
C-Reactive 蛋白 (Human) 能够与细菌细胞表面表达的磷脂酰胆碱结合，如肺炎球菌，这会激活补体系统，促进巨噬细胞的吞噬作用，从而清除坏死和凋亡的细胞及细菌^[4,5]。
C-Reactive 蛋白 (Human) 结合微生物上的磷脂酰胆碱，这有助于补体结合外来损伤细胞，并增强巨噬细胞的吞噬作用。C-Reactive 蛋白 (Human) 作为对抗感染的早期防御系统在先天免疫中发挥重要作用^[4]
C-Reactive 蛋白 (Human) 是一种史前抗体，会与 Fc-gamma 受体 IIa 结合^[6]。

Human

HEK293

Tag Free

P02741 (Q19-P224)

1401  [NCBI]

Approximately 26 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 0.2M NaCl, 5 mM CaCl2, pH 8.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

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  [2]. Thompson D, et al. The physiological structure of human C-reactive protein and its complex with phosphocholine. Structure. 1999 Feb 15;7(2):169-77.  [Content Brief]

  [3]. Pepys MB, et al. C-reactive protein: a critical update. J Clin Invest. 2003 Jun;111(12):1805-12.  [Content Brief]

  [4]. Bray C, et al. Erythrocyte Sedimentation Rate and C-reactive Protein Measurements and Their Relevance in Clinical Medicine. WMJ. 2016 Dec;115(6):317-21.  [Content Brief]

  [5]. Enocsson H, et al. The Complex Role of C-Reactive Protein in Systemic Lupus Erythematosus. J Clin Med. 2021 Dec 13;10(24):5837.  [Content Brief]

  [6]. Sheriff A. Special Issue "C-Reactive Protein and Cardiovascular Disease: Clinical Aspects". J Clin Med. 2022 Jun 22;11(13):3610.  [Content Brief]

  [7]. Chen W, et al. Association of C-reactive protein gene polymorphisms with the risk of ischemic stroke: A systematic review and meta-analysis. Brain Behav. 2023 Jun;13(6):e2976.  [Content Brief]

  [8]. Li X, et al. Lymphocyte-to-C-Reactive Protein Ratio as an Early Sepsis Biomarker for Neonates with Suspected Sepsis. Mediators Inflamm. 2023 May 8;2023:9077787.  [Content Brief]

  [9]. Maillard O, et al. C-reactive protein: An easy marker for early differentiation between leptospirosis and dengue fever in endemic area. PLoS One. 2023 May 17;18(5):e0285900.  [Content Brief]

  [10]. Yang Z, et al. Unrevealing the shared genetic mechanisms underlying C-reactive protein and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Aug 30;126:110785.  [Content Brief]

  [11]. Andersson J, et al. C-reactive protein is a determinant of first-ever stroke: prospective nested case-referent study. Cerebrovasc Dis. 2009;27(6):544-51.  [Content Brief]