Fc gamma RIIA/CD32a 蛋白, Rhesus Macaque (HEK293, His)

The Fc γ RIIA/CD32a protein plays a key role by specifically binding to the Fc region of immunoglobulin γ, acting as a low-affinity receptor. Fc γ RIIA/CD32a initiates cellular responses against pathogens and soluble antigens and plays an important role in immune regulation. Fc γ RIIA/CD32a interacts with PI3K and Syk. Fc gamma RIIA/CD32a Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Fc gamma RIIA/CD32a protein, expressed by HEK293 , with C-His labeled tag. The total length of Fc gamma RIIA/CD32a Protein, Rhesus Macaque (HEK293, His) is 184 a.a., with molecular weight of ~25-35 kDa.

Fc γ RIIA/CD32a 蛋白通过特异性结合免疫球蛋白 γ 的 Fc 区发挥关键作用，作为低亲和力受体发挥作用。通过与 IgG 的相互作用，Fc γ RIIA/CD32a 启动针对病原体和可溶性抗原的细胞应答，在免疫调节中发挥重要作用。Fc γ RIIA/CD32a 蛋白促进了调理抗原的吞噬，进一步促进了免疫防御机制。此外，Fc γ RIIA/CD32a 与 IGHG1、INPP5D/SHIP1、INPPL1/SHIP2、APCS、FGR 和 HCK 相互作用，参与复杂的信号通路并调节其细胞功能。Fc γ RIIA/CD32a 与 PI3K 和 Syk 相互作用。

Measured by its binding ability in a functional ELISA. Immobilized Rhesus Macaque CD32a protein at 5 μg/mL (100 μL/well) can bind Human IgG1. The ED₅₀ for this effect is 0.8076 μg/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Rhesus Macaque CD32a protein at 5μg/mL(100μL/well) can bind Human IgG1. The ED₅₀ for this effect is 0.8076 μg/mL.

Rhesus Macaque

HEK293

C-His

H9BMP0 (Q34-I217)

719996  [NCBI]

QTAPPKAVLKLEPPWINVLREDSVTLTCGGAHSPDSDSTQWFHNGNLIPTHTQPSYMFKANNNDSGEYRCQTGRTSLSDPVHLTVLSEWLALQTTHLEFREGETIMLRCHSWKDKPLIKVAFFQNGKSKNFSHMNPNFSIPQANHSHSGDYHCTGNIGYTPYSSKPVTITVQVPSVGSSSPMGI

Approximately 25-35 kDa

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  Greater than 95% as determined by reducing SDS-PAGE. It migrates as an approximately 25-35 kDa band in SDS-PAGE under reducing conditions.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.