1. 重组蛋白
  2. CD Antigens
  3. Dendritic Cell CD Proteins Endothelial cell CD Proteins
  4. BDCA-4/CD304
  5. Neuropilin-1 蛋白, Mouse (HEK293, Fc)

Neuropilin-1 蛋白, Mouse (HEK293, Fc)

目录号: HY-P73312
COA 产品使用指南

Neuropilin-1 蛋白是一种重要受体,对于心血管系统发育、血管生成、神经元回路形成和非神经系统器官发生至关重要。它介导信号蛋白的化学脉冲活性,识别配体上的 C 端规则基序,并促进细胞内化和血管渗漏。Neuropilin-1 蛋白, Mouse (HEK293, Fc) 是重组的 Neuropilin-1 蛋白,由 HEK293 表达,带有 C-mFc 标签。

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规格 价格 是否有货 数量
100 μg ¥4000 In-stock
> 100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

Neuropilin-1 protein is an important receptor critical for cardiovascular system development, angiogenesis, neuronal circuit formation, and non-nervous system organogenesis.It mediates the chemical pulse activity of signaling proteins, recognizes C-terminal regular motifs on ligands, and promotes cellular internalization and vascular leakage.Neuropilin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Neuropilin-1 protein, expressed by HEK293 , with C-mFc labeled tag.

研究背景

Neuropilin-1 蛋白作为一种受体,对于心血管系统的发育、血管生成、特定神经元回路的形成以及神经系统外的器官发生至关重要。作为信号蛋白化学脉冲活性的介体,它识别其配体上的 C 端规则 (CendR) 基序 R/KXXR/K,促进细胞内化和血管渗漏。Neuropilin-1 与信号蛋白 3A (SEMA3A)、PGF 的 PLGF-2 亚型以及 VEGFA 和 VEGFB 的 VEGF165 亚型结合。与 KDR 共表达可增强 VEGF165 与 KDR 的结合并增强趋化性。该蛋白调节 VEGF 诱导的血管生成,并启动对胚胎发育过程中运动神经元轴突引导和细胞体迁移至关重要的信号通路。此外,Neuropilin-1 通过与 ABCB8/MITOSUR 相互作用在调节线粒体铁转运中发挥作用。它与 NRP2 形成同二聚体和异二聚体,结合 PLXNB1,并与线粒体中的 FER、VEGFA 和 ABCB8/MITOSUR 相互作用。

生物活性

Immobilized Mouse VEGF164 at 2 μg/ml (100 μl/well) can bind Mouse Neuropilin-1 mFc, the EC50 of Mouse Neuropilin-1 mFc is 4.0-20.0 ng/mL.

种属

Mouse

表达系统

HEK293

标签

C-mFc

蛋白编号

P97333 (M1-P856)

基因 ID
蛋白结构
N-term
Neuropilin-1 (M1-P856)
Accession # P97333
mFc
C-term
同用名
Neuropilin-1, His; CD304; NRP1; NRPNP1; VEGF165R; BDCA4
分子量

Approximately 120 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from sterile PBS, pH 7.4, 5% Trehalose, 5% Mannitol, 0.01% Tween-80.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Neuropilin-1 Protein, Mouse (HEK293, Fc)
目录号:
HY-P73312
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