Placental Lactogen/CSH1 蛋白, Human (HEK293, His)

Placental Lactogen/CSH1 Protein, exclusive to pregnancy, orchestrates lactation, fetal growth, and metabolism. Its unique mode of action involves zinc-induced dimerization of the Prolactin Receptor (PRLR), distinct from the Growth Hormone Receptor (GHR). This specificity and structural versatility underline its pivotal role in intricate pregnancy-related processes and maternal physiology. Placental Lactogen/CSH1 Protein, Human (HEK293, His) is the recombinant human-derived Placental Lactogen/CSH1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Placental Lactogen/CSH1 Protein, Human (HEK293, His) is 191 a.a., with molecular weight of ~22-24 kDa.

胎盘泌乳原/CSH1 蛋白专门在怀孕期间产生，在协调泌乳、胎儿生长和代谢过程中发挥着关键作用。值得注意的是，它表现出独特的作用模式，因为它不与生长激素受体 (GHR) 相互作用。相反，它的激活完全是通过锌诱导的催乳素受体（PRLR）二聚化介导的。这种独特的机制有助于该蛋白质的特异性，并强调其在与妊娠和母体生理相关的复杂过程中的重要性。值得注意的是，胎盘泌乳素/CSH1 可以单体和二聚体形式存在，突出了其结构的多功能性。

Measured in a cell proliferation assay using Nb211 rat lymphoma cells. The ED₅₀ for this effect is 0.2359 ng/mL, corresponding to a specific activity of 4.240 x 10⁶ units/mg.

Human

HEK293

C-6*His

P0DML2 (V27-F217)

1442  [NCBI]

VQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLRSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHDALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF

Approximately 22-24kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.