CSH1 - chorionic somatomammotropin hormone 1 Gene

中文名称：绒毛膜促生长激素 1

种属: Homo sapiens

同用名: PL; CSA; CS-1; CSMT; GHB3; hCS-1; hCS-A

基因 ID: 1442 | 基因类型: protein coding

关于 CSH1

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,894,918-63,896,574 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 5 paralogues. Restricted expression toward placenta (RPKM 9553.7).

功能概要

由该基因编码的蛋白质是生长激素/催乳素激素家族的成员，在生长控制中起着重要作用。该基因位于 17 号染色体上的生长激素位点，与其他四个转录方向相同的相关基因一起；一种被认为是由一系列基因复制进化而来的排列。虽然这五个基因具有非常高的序列同一性，但它们在不同组织中有选择性地表达。选择性剪接会产生五种生长激素中每一种的额外亚型，从而导致进一步的多样性和专业化的潜力。这个特殊的家族成员主要在胎盘中表达并利用多个转录起始位点。绒毛膜促生长激素激素 1 和 2 的相同成熟蛋白的表达在发育过程中被上调，尽管 1 与 2 的比例随足月增加。该基因的突变会导致胎盘催乳素缺乏和 Silver-Russell 综合征。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the somatotropin/Prolactin family of Hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth Hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin Hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]

CSH1 基因产物(1)

mRNA	Protein	Name
NM_001317.6	NP_001308.1	chorionic somatomammotropin hormone 1 precursor

CSH1 蛋白结构

Hormone_1

0
100
200
217 a.a.

蛋白主名

其他名称

chorionic somatomammotropin hormone 1

Chorionic somatomammotropin hormone 2

重组 CSH1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7871	Placental Lactogen/CSH1 Protein, Human (HEK293, His)	P0DML2 (V27-F217)	≥95%
HY-P77146	Placental Lactogen/CSH1 Protein, Human (217a.a, HEK293, His)	P0DML2 (M1-F217)	≥95%
HY-P77147	Placental Lactogen/CSH1 Protein, Human (Biotinylated, HEK293, His)	P0DML2 (V27-F217)	≥95%

关联疾病

疾病名称

别名

Choriocarcinoma

Chorioepithelioma

Epithelioid Trophoblastic Tumor

Trophoblastic Tumor, Epithelioid

Testicular Trophoblastic Tumor

Choriocarcinoma Of Ovary

Ovarian Choriocarcinoma

Gestational Choriocarcinoma

Gestational Chorionepithelioma

Molar Pregnancy With Choriocarcinoma

Non-Gestational Choriocarcinoma

Choriocarcinoma, Non-Gestational

Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation	Fetal Circulation
Persistent Pulmonary Hypertension Of The Newborn	Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Persistent Foetal Circulation	Persistent Foetal Circulation Syndrome
Pfc - [Persistent Fetal Circulation] Syndrome	Pphn - [Persistent Pulmonary Hypertension Of The Newborn]
Newborn Pulmonary Hypertension	Primary Pulmonary Hypertension Of Newborn

Non-Gestational Ovarian Choriocarcinoma

Placental Site Trophoblastic Tumor

Trophoblastic Tumor Placental Site	Trophoblastic Tumor, Placental Site
Placental Site Trophoblastic Tumour	Placental-Site Gestational Trophoblastic Neoplasm
Placenta Neoplasm	Psst
Deciduoma	Placental Cancer
Primary Malignant Neoplasm Of Placenta

Gestational Ovarian Choriocarcinoma

Supine Hypotensive Syndrome

Maternal Hypotension Syndrome	Antepartum Maternal Hypotension Syndrome
Postpartum Maternal Hypotension Syndrome	Maternal Hypotension Syndrome, Antepartum Condition Or Complication
Maternal Hypotension Syndrome, Postpartum Condition Or Complication	Maternal Hypotension Syndrome, Unspecified Trimester

Chronic Interstitial Cystitis

Rete Ovarii Benign Neoplasm

Rete Ovarii Adenoma

Adenoma Of Rete Ovarii

Placental Choriocarcinoma

Choriocarcinoma Of The Placenta

Corpus Luteum Cyst

Cystic Corpus Luteum	Luteal Cystic Ovary Disease
Lutein Cyst	Granulosa Lutein Cyst

Trophoblastic Neoplasm

Trophoblastic Tumor

Trophoblastic Neoplasms

Rh Isoimmunization

Rh Incompatibility Affecting Management Of Mother

Mixed Germ Cell Cancer

Mixed Germ Cell Tumor	Mixed Germ Cell Neoplasm
Mixed Germ Cell Tumour	Mixed Teratoma And Seminoma

Gestational Trophoblastic Neoplasm

Hydatidiform Mole	Molar Pregnancy
Gestational Trophoblastic Neoplasia	Gestational Trophoblastic Tumor
Gtn	Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasms	Hydatidiform Mole, Recurrent, 1
Hydatidiform Mole Benign	Trophoblastic Disease
Trophoblastic Disease Nos	Trophoblastic Disorder
Vesicular Mole Nos	Vesicular Mole
Hydatidiform Mole Nos

Placenta Disease

Placenta Diseases	Placenta Disorder
Pregnancy Complications	Placenta Disorders

Ectopic Pregnancy

Eccyesis	Pregnancy Ectopic
Pregnancy, Ectopic	Ectopic Pregnancies
Extrauterine Gestation Or Pregnancy	Extrauterine Pregnancy
Ep - [Ectopic Pregnancy]	Ectopic Mole
Aborted Ectopic Pregnancy	Ruptured Ectopic Pregnancy

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03236	CSH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CSH1	MGD	MGI:95707

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CSH1 - chorionic somatomammotropin hormone 1 Gene

关于 CSH1

功能概要

CSH1 基因产物(1)

CSH1 蛋白结构

重组 CSH1 蛋白

关联疾病

直系同源

热门区域

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CSH1 - chorionic somatomammotropin hormone 1 Gene

关于 CSH1

功能概要

CSH1 基因产物(1)

CSH1 蛋白结构

重组 CSH1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z