PTPRD 蛋白, Human (HEK293, His)

PTPRD protein is a receptor-type protein tyrosine phosphatase involved in various cellular processes related to cytoskeletal proteins. It regulates cell adhesion, motility, migration, cell cycle, neuronal growth, ion channel regulation, immune response, cancer cell invasion and apoptosis. PTPRD Protein, Human (HEK293, His) is the recombinant human-derived PTPRD protein, expressed by HEK293 , with C-His labeled tag.

PKCE 是一种不依赖于钙、磷脂和二酰甘油 (DAG) 依赖性的丝氨酸/苏氨酸蛋白激酶，在调节与细胞骨架蛋白相关的各种细胞过程中发挥着至关重要的作用。它参与细胞粘附、运动、迁移、细胞周期、神经元生长、离子通道调节、免疫反应、癌细胞侵袭和凋亡。PKCE 介导整合素依赖性信号传导，影响细胞与细胞外基质的粘附，并磷酸化 MARCKS、PTK2/FAK、波形蛋白 (VIM)、角蛋白 8 (KRT8) 和 IQGAP1 等蛋白质，以调节多种细胞功能。它有助于响应生长因子的细胞迁移，参与胞质分裂，调节心肌细胞中的肌丝功能，并参与扩张型心肌病的发病机制。此外，PKCE 通过磷酸化各种底物（包括 GABRG2、TRPV1、CACNA1B、STAT3、TICAM2/TRAM 和 NLRP5/MATER）来影响神经突生长、突触增强和免疫反应。它作为一种多方面的激酶出现，对细胞生理学和病理学具有广泛的影响。

Human

HEK293

C-His

P23468-1 (E21-E1265)

5789  [NCBI]

120&15 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.