PTPRD - protein tyrosine phosphatase receptor type D Gene

中文名称：蛋白酪氨酸磷酸酶受体 D 型

种属: Homo sapiens

同用名: HPTP; PTPD; HPTPD; HPTPDELTA; RPTPDELTA; R-PTP-delta

基因 ID: 5789 | 基因类型: protein coding

关于 PTPRD

Cytogenetic location: 9p24.1-p23 Genomic coordinates (GRCh38): 9:8,314,246-10,613,002 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 274 orthologues, 35 paralogues and is associated with 129 phenotypes. Broad expression in brain (RPKM 18.0), kidney (RPKM 8.8) and 14 other tissues.

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 包含一个细胞外区域、一个跨膜区段和两个串联的胞质内催化结构域，因此代表受体型 PTP。该蛋白的细胞外区域由三个 Ig 样结构域和八个 III 型纤连蛋白样结构域组成。对鸡和苍蝇中相似基因的研究表明，这种 PTP 的作用是促进神经突生长和调节神经元轴突导向。已经报道了该基因的多个选择性剪接的转录物变体。已在 5 号染色体上鉴定出一个相关的假基因。[RefSeq 提供，2010 年 1 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]

PTPRD 基因产物(10)

mRNA	Protein	Name
NM_001040712.2	NP_001035802.1	receptor-type tyrosine-protein phosphatase delta isoform 5 precursor
NM_001171025.2	NP_001164496.1	receptor-type tyrosine-protein phosphatase delta isoform 6 precursor
NM_001377946.1	NP_001364875.1	receptor-type tyrosine-protein phosphatase delta isoform 7 precursor
NM_001377947.1	NP_001364876.1	receptor-type tyrosine-protein phosphatase delta isoform 8 precursor
NM_001377958.1	NP_001364887.1	receptor-type tyrosine-protein phosphatase delta isoform 9 precursor
NM_001378058.1	NP_001364987.1	receptor-type tyrosine-protein phosphatase delta isoform 10 precursor
NM_002839.4	NP_002830.1	receptor-type tyrosine-protein phosphatase delta isoform 1 precursor
NM_130391.4	NP_569075.2	receptor-type tyrosine-protein phosphatase delta isoform 2 precursor
NM_130392.3	NP_569076.2	receptor-type tyrosine-protein phosphatase delta isoform 3 precursor
NM_130393.3	NP_569077.2	receptor-type tyrosine-protein phosphatase delta isoform 4 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12570871	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in presynapse assembly	IDA IDA: 通过直接分析推断	21926414	GOA
involved in presynapse assembly	IMP IMP: 通过突变表型推断	21926414	GOA
involved in synaptic membrane adhesion	IDA IDA: 通过直接分析推断	23345436	GOA
involved in synaptic membrane adhesion	IMP IMP: 通过突变表型推断	23345436	GOA
involved in trans-synaptic signaling by trans-synaptic complex	IDA IDA: 通过直接分析推断	21926414	GOA
involved in trans-synaptic signaling by trans-synaptic complex	IMP IMP: 通过突变表型推断	21926414	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	21926414	GOA
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	21926414	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTPRD 蛋白结构

I-set

fn3

Y_phosphatase

0
300
600
900
1200
1500
1800
1912 a.a.

蛋白主名

其他名称

receptor-type tyrosine-protein phosphatase delta

protein tyrosine phosphatase, receptor type, delta polypeptide

PTPRD 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PTPRD	P23468	AURKA	Homo sapiens	O14965	Anti Tag CoIP	22305495
种属内	PTPRD	P23468	AURKA	Homo sapiens	O14965	Protein Array	22305495

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PTPRD 蛋白

目录号	产品名	蛋白编号	纯度
HY-P78721	PTPRD Protein, Human (HEK293, His)	P23468-1 (E21-E1265)	≥95%

关联疾病

疾病名称

别名

Restless Legs Syndrome

Wed	Willis-Ekbom Disease
Restless Leg Syndrome	Ekbom Syndrome
Wittmaack-Ekbom Syndrome	Willis Ekbom Disease
Ekbom'S Syndrome	Rls
Restless Legs	Restless Legs Syndrome, Susceptibility To

Chromosome 9p Deletion Syndrome

Monosomy 9p	Monosomy 9p Syndrome
Alfi Syndrome	9p Syndrome
Chromosome 9p Deletion	9p Deletion
9p Monosomy	Deletion 9p
Partial Monosomy 9p	9p Deletion Syndrome
9p- Syndrome	Alfi'S Syndrome
Chromosome 9, Partial Trisomy 9p

Obsessive-Compulsive Disorder

OCD	Obsessive-Compulsive Disorder, Susceptibility To
Anancastic Neurosis	Obsessive Compulsive Disorder
Anankastic Neurosis	Obsessive-Compulsive Neurosis
Obsessive Compulsive Behavior

Hypermethioninemia Due To Adenosine Kinase Deficiency

Adk Hypermethioninemia	Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency
Hypermethioninemia Encephalopathy Due To Adk Deficiency	Mrt8
Mental Retardation, Autosomal Recessive 8, Formerly	Mrt8, Formerly
HMAKD	Mental Retardation, Autosomal Recessive 8

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-115496	7-BIA	Inhibitor	≥98.0%	否
HY-RS11436	PTPRD Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PTPRD	VGNC	VGNC:69171
Bos taurus	PTPRD	VGNC	VGNC:33548
Canis familiaris	PTPRD	VGNC	VGNC:45185
Mus musculus	PTPRD	MGD	MGI:97812
Rattus norvegicus	PTPRD	RGD	RGD:1561090
Macaca mulatta	PTPRD	VGNC	VGNC:76614
Others	PTPRD	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PTPRD - protein tyrosine phosphatase receptor type D Gene

关于 PTPRD

功能概要

PTPRD 基因产物(10)

PTPRD 蛋白结构

PTPRD 蛋白互作信息

重组 PTPRD 蛋白

关联疾病

直系同源

热门区域

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PTPRD - protein tyrosine phosphatase receptor type D Gene

关于 PTPRD

功能概要

PTPRD 基因产物(10)

PTPRD 蛋白结构

PTPRD 蛋白互作信息

重组 PTPRD 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z