S100A13 蛋白, Human

The S100A13 protein is critical for unconventional protein export, binding calcium and copper ions without interference. It is essential for copper-dependent stress-induced export of IL1A and FGF1. S100A13 Protein, Human is the recombinant human-derived S100A13 protein, expressed by E. coli , with tag free. The total length of S100A13 Protein, Human is 97 a.a., with molecular weight of ~12.0 kDa.

S100A13 是一种多功能蛋白质，在不含信号肽的蛋白质的非常规输出中发挥着关键作用。这一功能是通过其每个亚基结合两个钙离子和一个铜离子的能力来协调的，铜的结合不会阻碍钙的结合。值得注意的是，S100A13 对于铜依赖性应激诱导的 IL1A 和 FGF1 输出是不可或缺的。在无钙状态下，该蛋白质对含有磷脂酰丝氨酸的脂质囊泡表现出亲和力，从而区分其膜相互作用偏好。在结构上，S100A13 形成同二聚体，与 FGF1 和 SYT1 一起构成铜依赖性多蛋白复合物。这些复杂的相互作用强调了 S100A13 在通过替代途径介导特定蛋白质输出方面的调节作用，有助于细胞稳态。此外，该蛋白与 IL1A 直接相互作用，进一步扩展了其分子伙伴关系的范围。

Human

E. coli

Tag Free

Q99584 (A2-K98)

6284  [NCBI]

AAEPLTELEESIETVVTTFFTFARQEGRKDSLSVNEFKELVTQQLPHLLKDVGSLDEKMKSLDVNQDSELKFNEYWRLIGELAKEIRKKKDLKIRKK

Approximately 12.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 1mM CaCl₂, 0.1% Tween-20, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.