2. Gene
  3. S100A13 - S100 calcium binding protein A13 Gene

S100A13 - S100 calcium binding protein A13 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：S100 钙结合蛋白 A13

种属: Homo sapiens

基因 ID: 6284 | 基因类型: protein coding

关于 S100A13

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,618,799-153,634,361 (from NCBI)

This gene has 6 transcripts (splice variants), 162 orthologues and 21 paralogues. Broad expression in heart (RPKM 156.8), fat (RPKM 39.4) and 16 other tissues.

功能概要

由该基因编码的蛋白质是包含 2 个 EF 手钙结合基序的 S100 蛋白质家族的成员。 S100 蛋白定位于多种细胞的细胞质和/或细胞核，并参与许多细胞过程的调节，例如细胞周期进程和分化。 S100 基因包括至少 13 个成员，它们成簇地位于染色体 1q21 上。该蛋白广泛表达于多种组织，在甲状腺中表达量较高。在平滑肌细胞中，这种蛋白质与细胞核和应力纤维中的其他家族成员共同表达，表明在信号转导中具有多种功能。已为该基因发现了编码相同蛋白质的多个可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with Other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

S100A13 基因产物(5)

mRNA Protein Name
NM_001024210.2 NP_001019381.1 protein S100-A13
NM_001024211.2 NP_001019382.1 protein S100-A13
NM_001024212.2 NP_001019383.1 protein S100-A13
NM_001024213.2 NP_001019384.1 protein S100-A13
NM_005979.3 NP_005970.1 protein S100-A13
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RAGE receptor binding IPI
IPI: 通过物理相互作用推断
15033494 GOA
enables calcium ion binding IDA
IDA: 通过直接分析推断
16145699 GOA
enables copper ion binding IDA
IDA: 通过直接分析推断
12746488 GOA
enables fibroblast growth factor binding IPI
IPI: 通过物理相互作用推断
11432880 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12746488 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
12746488 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
12118070 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
15033494 GOA
involved in positive regulation of cytokine production IMP
IMP: 通过突变表型推断
20863990 GOA
involved in positive regulation of interleukin-1 alpha production IDA
IDA: 通过直接分析推断
12746488 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15821778 GOA
located in cytosol IDA
IDA: 通过直接分析推断
12746488 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
12746488 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12118070 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
10722710 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

S100A13 蛋白结构

S_100

S_100: S-100/ICaBP type calcium binding domain (9 - 51)

  • 0
  • 98 a.a.
蛋白主名 其他名称

protein S100-A13

S100A13 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
S100A13 Q99584 TNF Homo sapiens P01375
Crosslink
36555597
种属内
S100A13 Q99584 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
25416956
种属内
S100A13 Q99584 S100A14 Homo sapiens Q9HCY8
Validated Y2H
32296183
种属内
S100A13 Q99584 S100A14 Homo sapiens Q9HCY8
Y2H Array
32296183
种属内
S100A13 Q99584 S100A14 Homo sapiens Q9HCY8
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 S100A13 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71271 S100A13 Protein, Human Q99584 (A2-K98) ≥95%

关联疾病

疾病名称 别名
Trachea Leiomyoma

Tracheal Neoplasms

Leiomyoma Of The Trachea

Tracheal Neoplasm

Tracheal Leiomyoma
Conjunctival Intraepithelial Neoplasm

Intraepithelial Neoplasia Of Conjunctiva

Conjunctival Intraepithelial Neoplasia
Chorioangioma

Placental Hemangioma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12375 S100A13 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus S100A13 VGNC VGNC:34239
Rattus norvegicus S100A13 RGD RGD:1304919
Canis familiaris S100A13 VGNC VGNC:45825
Mus musculus S100A13 MGD MGI:109581
Others S100A13 NCBI
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