Sorcin/SRI 蛋白, Human (sf9, His-GST)

Sorcin/SRI protein, a calcium-binding modulator, intricately regulates excitation-contraction coupling in the heart and plays a crucial role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI exerts its influence on the activity of RYR2 calcium channels, contributing to the precise control of calcium dynamics in cardiac muscle cells. Its interactions with GCA, RYR2, and ANXA7 underscore its involvement in complex molecular networks, suggesting a multifaceted role in cellular processes related to calcium signaling and homeostasis. In the context of the heart, Sorcin/SRI emerges as a key player in the orchestration of calcium-dependent events, emphasizing its significance in the fine-tuning of excitation-contraction coupling and intracellular calcium regulation. Sorcin/SRI Protein, Human (sf9, His-GST) is the recombinant human-derived Sorcin/SRI protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Sorcin/SRI Protein, Human (sf9, His-GST) is 198 a.a., with molecular weight of ~47 kDa.

Sorcin/SRI 蛋白是一种钙结合调节剂，复杂地调节心脏中的兴奋-收缩耦合，并在维持肌浆网内的钙稳态中发挥着至关重要的作用。作为同二聚体，Sorcin/SRI 对 RYR2 钙通道的活性产生影响，有助于精确控制心肌细胞中的钙动态。它与 GCA、RYR2 和 ANXA7 的相互作用强调了它参与复杂的分子网络，表明在与钙信号传导和稳态相关的细胞过程中发挥多方面的作用。在心脏的背景下，Sorcin/SRI 在钙依赖性事件的协调中发挥着关键作用，强调了其在兴奋-收缩耦合和细胞内钙调节的微调中的重要性。

Human

Sf9 insect cells

N-His;N-GST

P30626 (M1-V198)

6717  [NCBI]

Approximately 47 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.