2. Gene
  3. SRI - sorcin Gene

SRI - sorcin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：解毒素

种属: Homo sapiens

同用名: SCN; V19; CP22; CP-22

基因 ID: 6717 | 基因类型: protein coding

关于 SRI

Cytogenetic location: 7q21.12 Genomic coordinates (GRCh38): 7:88,205,115-88,226,976 (from NCBI)

This gene has 10 transcripts (splice variants), 173 orthologues and 20 paralogues. Broad expression in colon (RPKM 86.4), brain (RPKM 64.5) and 24 other tissues.

功能概要

该基因编码具有多个 EF 手结构域的钙结合蛋白，响应钙水平升高，从细胞质重新定位到肌浆网。除了调节细胞内钙稳态外，它还调节心脏的兴奋-收缩偶联。可变剪接导致编码不同蛋白质的多个转录变体。该基因存在多个假基因。[RefSeq 提供，2012 年 3 月]

This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]

SRI 基因产物(4)

mRNA Protein Name
NM_001256891.2 NP_001243820.1 sorcin isoform C
NM_001256892.2 NP_001243821.1 sorcin isoform D
NM_003130.4 NP_003121.1 sorcin isoform A
NM_198901.2 NP_944490.1 sorcin isoform B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
17215369 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17699613 GOA
enables protease binding IPI
IPI: 通过物理相互作用推断
10748169 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9268363 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
12804766 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of heart rate IMP
IMP: 通过突变表型推断
12754254 GOA
involved in negative regulation of ryanodine-sensitive calcium-release channel activity IDA
IDA: 通过直接分析推断
17699613 GOA
involved in regulation of calcium ion transport IMP
IMP: 通过突变表型推断
12754254 GOA
involved in regulation of cardiac muscle cell contraction IMP
IMP: 通过突变表型推断
12754254 GOA
involved in regulation of cell communication by electrical coupling involved in cardiac conduction IMP
IMP: 通过突变表型推断
17130302 GOA
involved in regulation of high voltage-gated calcium channel activity IMP
IMP: 通过突变表型推断
12754254 GOA
involved in regulation of relaxation of muscle IMP
IMP: 通过突变表型推断
12754254 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
12754254 GOA
colocalizes with chromaffin granule membrane IDA
IDA: 通过直接分析推断
9268363 GOA
located in cytosol IDA
IDA: 通过直接分析推断
10748169 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
10672515 GOA
located in extracellular exosome IDA
IDA: 通过直接分析推断
15326289 GOA
located in membrane IDA
IDA: 通过直接分析推断
10748169 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SRI 蛋白结构

EF-hand_8

EF-hand_8: EF-hand domain pair (45 - 101)

EF-hand_7

EF-hand_7: EF-hand domain pair (107 - 161)

  • 0
  • 100
  • 198 a.a.
蛋白主名 其他名称

sorcin

22 kDa protein

重组 SRI 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77210 Sorcin/SRI Protein, Human (sf9) P30626 (M1-V198) ≥95%
HY-P77211 Sorcin/SRI Protein, Human (sf9, His-GST) P30626 (M1-V198) ≥95%
HY-P700311 Sorcin/SRI Protein, Human (E.coli, GST) P30626 (M1-V198) ≥95%

关联疾病

疾病名称 别名
Overhydrated Hereditary Stomatocytosis

Ohs

Potassium Sodium Disorder Of Erythrocyte

OHST

Stomatocytosis I

Potassium-Sodium Disorder Of Erythrocyte

Stomatocytosisiohst

Hereditary, Overhydrated, Cation-Leak Stomatocytosis

Overhydrated Cation Leak Stomatocytosis

Stomatocytosis, Overhydrated Hereditary
Apical Myocardial Infarction
Severe Congenital Neutropenia

Congenital Neutropenia

Neutropenia, Severe Congenital

Congenital Agranulocytosis

Infantile Genetic Agranulocytosis

Kostmann Disease

Kostmann'S Agranulocytosis

Kostmann'S Syndrome

Severe Infantile Genetic Neutropenia
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100347A SRI-011381 hydrochloride Agonist 99.55% 否
HY-19956 GI254023X Inhibitor 99.67% 否
HY-100347 SRI-011381 Agonist 99.58% 否
HY-142114 SRI-37330 Inhibitor 98.76% 否
HY-141623 SRI-37330 hydrochloride Inhibitor 99.58% 否
HY-150090 SRI-41315 Activator 99.94% 否
HY-114363A SRI 31215 TFA Inhibitor 98.53% 否
HY-148853 SRI-42127 Inhibitor 99.80% 否
HY-150089 SRI-37240 Modulator 99.21% 否
HY-123600 SRI-29329 Inhibitor 99.73% 否
HY-117002 SRI 37892 Inhibitor 98.92% 否
HY-112580 SRI-31040 / 否
HY-126158 SRI-29574 / 否
HY-147251 SRI 6409-94 98.60% 否
HY-160783 SRI-43265 Inhibitor 99.08% 否
HY-RS13767 SRI Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-117902 SRI-31142 / 否
HY-N9533 16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SRI RGD RGD:1584485
Canis familiaris SRI VGNC VGNC:46804
Macaca mulatta SRI VGNC VGNC:81763
Mus musculus SRI MGD MGI:98419
Felis catus SRI VGNC VGNC:65681
Bos taurus SRI VGNC VGNC:35281
Macaca fascicularis SRI NCBI NCBI:102138728
Others SRI NCBI
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