STX7 蛋白, Human (HEK293, His)

The STX7 protein plays a key role in protein trafficking and membrane fusion events. It guides proteins from the plasma membrane to early endosomes, facilitates homotypic fusion of endocytic organelles, and mediates transport from early endosomes to late endosomes and lysosomes. STX7 Protein, Human (HEK293, His) is the recombinant human-derived STX7 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of STX7 Protein, Human (HEK293, His) is 237 a.a., with molecular weight of 31-36 kDa.

STX7 蛋白在控制蛋白质运输和膜融合事件的细胞过程中发挥着关键作用。它涉及蛋白质从质膜到早期内体 (EE) 的运输，并有助于内吞细胞器的同型融合。此外，STX7 介导从早期内体到晚期内体和溶酶体的内吞运输，强调了其在内体区室动态调节中的作用。通过与 VTI1B、STX8 和 VAMP8 形成 SNARE 复合物，STX7 在晚期内涵体的同型融合中发挥着至关重要的作用。它与 STX8、VAMP7 和 VTI1B 一样，也是 SNARE 复合体的组成部分，对于晚期内涵体与溶酶体的异型融合至关重要。与 VPS11、VPS16、VPS18、VPS33A 和 TPC1 的相互作用强调了复杂的关联网络，揭示了 STX7 在内吞途径中协调膜融合事件和蛋白质运输的多方面参与。研究 STX7 功能的详细机制可以为其在细胞膜动力学中的调节作用提供有价值的见解。

Human

HEK293

N-6*His

O15400 (S2-L238)

8417  [NCBI]

SYTPGVGGDPAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQDSPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKVQRQAAEREKEFVARVRASSRVSGSFPEDSSKERNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQRKSRKTL

31-36 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.