TrkA 蛋白, Human (HEK293, His-Fc)

TrkA protein is an important receptor tyrosine kinase that regulates the development of the central and peripheral nervous systems and affects the proliferation, differentiation, and survival of neurons. As a high-affinity receptor for NGF, TrkA is activated upon NGF binding through homodimerization and autophosphorylation. TrkA Protein, Human (HEK293, His-Fc) is the recombinant human-derived TrkA protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of TrkA Protein, Human (HEK293, His-Fc) is 382 a.a., with molecular weight of 85-95 kDa.

TrkA 蛋白是一种受体酪氨酸激酶，在中枢和周围神经系统的发育和成熟中发挥着至关重要的作用，控制交感神经元和感觉神经元的增殖、分化和存活。TrkA 作为 NGF（其主要配体）的高亲和力受体发挥作用，在二聚体 NGF 配体结合后经历同二聚化、自磷酸化和激活。这种激活导致下游效应子（包括 SHC1、FRS2、SH2B1、SH2B2 和 PLCG1）的募集、磷酸化和/或激活，协调驱动细胞存活和分化的不同信号级联。TrkA 通过 GRB2-Ras-MAPK 级联、Ras-PI3 激酶-AKT1 信号传导和 NF-Kappa-B 激活等途径调节多种细胞过程。在没有配体和激活的情况下，TrkA 可能导致细胞死亡，强调神经元存活对营养因子的依赖性。有趣的是，它表现出对 NGF 的抗性，持续激活 AKT1 和 NF-kappa-B，但无法激活 Ras-MAPK 信号级联。TrkA 还拮抗抗增殖 NGF-NTRK1 信号传导，促进神经元前体分化。同种型 TrkA-III 另外在血管生成中发挥作用，并在过度表达时表现出致癌活性。

Human

HEK293

C-hFc;C-His

P04629 (M1-P382)

4914  [NCBI]

85-95 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.