2. 天然产物
  3. 植物 黄酮类
  4. 卷柏科 双黄酮
  5. 鳞叶卷柏
  6. Robustaflavone

Robustaflavone 是一种可以从 Doradilla 中分离得到的双黄酮类化合物，具有利尿钠作用。

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Robustaflavone Chemical Structure

Robustaflavone Chemical Structure

CAS No. : 49620-13-5

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规格 价格 是否有货 数量
1 mg ￥3960
In-stock
5 mg 现货 询价
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Customer Review

Robustaflavone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Robustaflavone is a biflavonoid isolated from Doradilla that has natriuretic properties[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
21.38 μM
Compound: 7
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 29921475]
Calu-1 IC50
> 100 μM
Compound: 5
Cytotoxicity against human Calu1 cells after 3 days
Cytotoxicity against human Calu1 cells after 3 days
[PMID: 10843573]
HeLa IC50
> 100 μM
Compound: 5
Cytotoxicity against human HeLa cells after 3 days
Cytotoxicity against human HeLa cells after 3 days
[PMID: 10843573]
HepG2 EC50
0.25 μM
Compound: Robustaflavone (RF)
Effective concentration necessary to decrease extracellular Hepatitis B virus DNA levels by 50% in human hepatoblastoma cell line (2.2.15 cells) in vitro
Effective concentration necessary to decrease extracellular Hepatitis B virus DNA levels by 50% in human hepatoblastoma cell line (2.2.15 cells) in vitro
10.1016/S0960-894X(97)00422-8
HepG2 IC50
19.15 μM
Compound: 7
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 29921475]
HepG2 IC50
337 μM
Compound: Robustaflavone (RF)
Cytotoxicity towards human hepatoblastoma cell line (2.2.15 cells) measured by inhibition of neutral red dye uptake in vitro
Cytotoxicity towards human hepatoblastoma cell line (2.2.15 cells) measured by inhibition of neutral red dye uptake in vitro
10.1016/S0960-894X(97)00422-8
K562 IC50
> 100 μM
Compound: 5
Cytotoxicity against human K562 cells after 3 days
Cytotoxicity against human K562 cells after 3 days
[PMID: 10843573]
MGC-803 IC50
15.57 μM
Compound: 7
Cytotoxicity against human MGC803 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MGC803 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 29921475]
Neutrophil IC50
0.45 μM
Compound: 6
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate
[PMID: 29381070]
Neutrophil IC50
1.01 μM
Compound: 6
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase
[PMID: 29381070]
PBMC IC50
77 μM
Compound: 3
Cytotoxicity against uninfected PHA-stimulated human PBMC assessed as thymidine incorporation after 24 hrs by trypan blue exclusion method
Cytotoxicity against uninfected PHA-stimulated human PBMC assessed as thymidine incorporation after 24 hrs by trypan blue exclusion method
[PMID: 9322359]
Raji IC50
> 100 μM
Compound: 5
Cytotoxicity against human Raji cells after 3 days
Cytotoxicity against human Raji cells after 3 days
[PMID: 10843573]
T-24 IC50
21.09 μM
Compound: 7
Cytotoxicity against human T24 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human T24 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 29921475]
Vero IC50
> 100 μM
Compound: 5
Cytotoxicity against african green monkey Vero cells after 3 days
Cytotoxicity against african green monkey Vero cells after 3 days
[PMID: 10843573]
WISH IC50
> 100 μM
Compound: 5
Cytotoxicity against human Wish cells after 3 days
Cytotoxicity against human Wish cells after 3 days
[PMID: 10843573]
分子量

538.46

Formula

C30H18O10
CAS 号
性状

固体

颜色

Light yellow to yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (18.57 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8571 mL 9.2857 mL 18.5715 mL
5 mM 0.3714 mL 1.8571 mL 3.7143 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Robustaflavone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8571 mL 9.2857 mL 18.5715 mL 46.4287 mL
5 mM 0.3714 mL 1.8571 mL 3.7143 mL 9.2857 mL
10 mM 0.1857 mL 0.9286 mL 1.8571 mL 4.6429 mL
15 mM 0.1238 mL 0.6190 mL 1.2381 mL 3.0952 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Robustaflavone49620-13-5OthersNatriuretic effectInhibitorinhibitorinhibit

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目录号：
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