2. Protein Tyrosine Kinase/RTK
  3. Btk FLT3
  4. RSH-7

RSH-7 是一种有效的 BTK 和 FLT3 抑制剂，IC50 分别为 47、12 nM。RSH-7 诱导细胞凋亡 (apoptosis) 并显示抗增殖活性。RSH-7 抑制 BTK 和 FLT3 信号转导并显示出抗肿瘤活性。

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RSH-7 Chemical Structure

RSH-7 Chemical Structure

CAS No. : 2764609-97-2

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5 mg ￥3200
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10 mg ￥5200
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Customer Review

RSH-7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RSH-7 is a potent BTK and FLT3 inhibitor with IC50s of 47, 12 nM, respectively. RSH-7 induces apoptosis and shows antiproliferative activities. RSH-7 inhibits BTK and FLT3 signaling and shows anti-tumor activity[1].

IC50 & Target

IC50: 47 nM (BTK); 12 nM (FLT3)[1]
体外研究
(In Vitro)

RSH-7 (1-1000 nM; 72 h) shows antiproliferative activities with IC50s of 17, 3, 11, 930 nM for Jeko-1, MV-4-11, Molt4, K562 cells, respectively[1].
RSH-7 (30, 150, 750 nM; 72 h) decreases the expression of p-BTK (TYR223), p-PLCγ(Tyr1217), p-FLT3 (Tyr589), p-STAT5 (TYR694) in a dose-dependent manner[1].
RSH-7 (30, 150, 750 nM; 72 h) induces apoptosis and increases the expression of BAX, p53, cleaved caspase 3 in a dose dependen manner in jeko-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RSH-7 相关抗体:

Cell Viability Assay[1]

Cell Line: Jeko-1, MV-4-11, Molt4, K562 cells
Concentration: 1-1000 nM
Incubation Time: 72 h
Result: Showed antiproliferative activities with IC50s of 17, 3, 11, 930 nM for Jeko-1, MV-4-11, Molt4, K562 cells, respectively.

Western Blot Analysis[1]

Cell Line: jeko-1 cells
Concentration: 30, 150, 750 nM
Incubation Time: 72 h
Result: Reduced both BTK, PLCγ2, FLT3 and STAT5 phosphorylation in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: jeko-1 cells
Concentration: 30, 150, 750 nM
Incubation Time: 72 h
Result: Dose-dependently induced cell apoptosis and upregulated the expression of pro-apoptotic protein BAX, p53, cleaved caspase 3.
体内研究
(In Vivo)

RSH-7 (25, 50 mg/kg; i.p.; daily for 16 days) shows anti-tumor activity with significantly and dose-dependently suppresses the tumor growth in mouse[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/SCID mice (jeko-1 cell-inoculated xenograft NOD/SCID mice models)[1]
Dosage: 25, 50 mg/kg
Administration: I.p.; daily for 16 days
Result: Suppressed tumor growth in a dose-dependent manner, with tumor growth inhibition (TGI) values of 66.95% and 79.78% at doses of 25 and 50 mg/kg,
Animal Model: Female NOD/SCID mice (MV4-11 cell-inoculated xenograft NOD/SCID mice models)[1]
Dosage: 10, 20 mg/kg
Administration: I.p.; daily for 21 days
Result: Significantly and dose-dependently suppressed the tumor growth with the TGI rates of 74.23% and 94.84% at the dosage of 10 and 20 mg/kg, respectively.
分子量

436.49

Formula

C22H25FN8O
CAS 号
性状

固体

颜色

Gray to dark gray

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 83.33 mg/mL (190.91 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2910 mL 11.4550 mL 22.9100 mL
5 mM 0.4582 mL 2.2910 mL 4.5820 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

RSH-7 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2910 mL 11.4550 mL 22.9100 mL 57.2751 mL
5 mM 0.4582 mL 2.2910 mL 4.5820 mL 11.4550 mL
10 mM 0.2291 mL 1.1455 mL 2.2910 mL 5.7275 mL
15 mM 0.1527 mL 0.7637 mL 1.5273 mL 3.8183 mL
20 mM 0.1146 mL 0.5728 mL 1.1455 mL 2.8638 mL
25 mM 0.0916 mL 0.4582 mL 0.9164 mL 2.2910 mL
30 mM 0.0764 mL 0.3818 mL 0.7637 mL 1.9092 mL
40 mM 0.0573 mL 0.2864 mL 0.5728 mL 1.4319 mL
50 mM 0.0458 mL 0.2291 mL 0.4582 mL 1.1455 mL
60 mM 0.0382 mL 0.1909 mL 0.3818 mL 0.9546 mL
80 mM 0.0286 mL 0.1432 mL 0.2864 mL 0.7159 mL
100 mM 0.0229 mL 0.1146 mL 0.2291 mL 0.5728 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RSH-72764609-97-2RSH7RSH 7BtkFLT3Bruton tyrosine kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3antiproliferativeapoptosisjeko-1 cellsp-BTKp-FLT3anti-tumorInhibitorinhibitorinhibit

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