2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. SDZ 220-581 Ammonium salt

SDZ 220-581 Ammonium salt 是一种口服生物利用度，有效的竞争性的 NMDA 受体拮抗剂，pKi 值为 7.7。

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SDZ 220-581 Ammonium salt Chemical Structure

SDZ 220-581 Ammonium salt Chemical Structure

CAS No. : 179411-94-0

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Other Forms of SDZ 220-581 Ammonium salt:

SDZ 220-581 Ammonium salt 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SDZ 220-581 Ammonium salt is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7[1].

IC50 & Target

pKi: 7.7 (NMDA receptor)[1]
体内研究
(In Vivo)

SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male OF-l mice (18-26 g)[1]
Dosage: 3.2 mg/kg, 10 mg/kg, 32 mg/kg
Administration: Oral administration; for 24 hours
Result: Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration.
分子量

386.77

Formula

C16H20ClN2O5P
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

SDZ 220-581 Ammonium salt 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SDZ 220-581179411-94-0iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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产品名称：
SDZ 220-581 Ammonium salt
目录号：
HY-13059A
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