2. Metabolic Enzyme/Protease Neuronal Signaling
  3. Epoxide Hydrolase Cholinesterase (ChE)
  4. sEH/AChE-IN-4

sEH/AChE-IN-4 (compound (+)-15) 是一种有效的、可透过血脑屏障的 sEH (可溶性环氧水解酶)和 AChE (乙酰胆碱酯酶)的双重抑制剂，其 IC50 分别为 3.1 nM (hsEH)、1660 nM (hAChE)、179 nM (hBChE，丁酰胆碱酯酶)、14.5 nM (msEH) 和 102 nM (mAChE)。

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sEH/AChE-IN-4 Chemical Structure

sEH/AChE-IN-4 Chemical Structure

CAS No. : 2490589-12-1

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sEH/AChE-IN-4 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively[1].

IC50 & Target

IC50: 3.1 nM (hsEH), 1660 ± 450 nM (hAChE), 179 ± 26 nM (hBChE), 14.5 nM (msEH), 102 ± 18 nM (mAChE)[1]
分子量

670.16

Formula

C35H39ClF3N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

sEH/AChE-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

sEH/AChE-IN-42490589-12-1Epoxide HydrolaseCholinesterase (ChE)SH-SY5Y cellsBBB permeabilitylow neurotoxicityAlzheimer’s diseasesoluble epoxide hydrolaseneuroinflammationmemory impairmentInhibitorinhibitorinhibit

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