Selepressin (Synonyms: FE 202158)

目录号: HY-105239 纯度: 99.34%: FAQs
Data Sheet SDS COA 产品使用指南技术支持

Selepressin (FE 202158) 是一种选择性的加压素 V_1A 受体 (vasopressin V_1A receptor) 激动剂。Selepressin 是一种有效的血管加压素。Selepressin 可用于脓毒性休克的研究。

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Selepressin Chemical Structure

CAS No. : 876296-47-8

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1 mg	￥3200	In-stock
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V1a Receptor V1b Receptor V2 Receptor

生物活性
纯度 & 产品资料
参考文献

生物活性

Selepressin (FE 202158) is a selective vasopressin V_1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock^[1]^[2]^[4].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	1100 nM Compound: 45, FE 202158	Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay	[PMID: 21688787]
Flp-In-293	EC₅₀	340 nM Compound: 45, FE 202158	Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	0.55 nM Compound: 45, FE 202158	Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	2.4 nM Compound: 45, FE 202158	Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	2700 nM Compound: 45, FE 202158	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 21688787]

体外研究
(In Vitro)

Selepressin (100 nM, 48 or 72 h) ameliorates thrombin or VEGF-induced HLMVECs barrier dysfunction^[3].
Selepressin (1-1000 nM, 72 h) prevents the LPS-Induced loss of VE-cadherin and cortical actin in HLMVECs^[3].
Selepressin (100 nM, 48 h) induces the expression of the barrier-protective p53 in HLMVECs^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	HLMVECs
Concentration:	1, 10, 100, 1000 nM
Incubation Time:	24 h, 48 h
Result:	Induced p53 expression levels, but only after treatment of 48 hours at 100 nM.

体内研究
(In Vivo)

Selepressin (1 μg/kg/min, left jugular vein infusion for 12 min) increases 38.5% of the mean arterial pressure (MAP) in LPS-induced, fluid-resuscitated rabbit endotoxemia model^[2].
Selepressin (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	LPS-induced, fluid-resuscitated rabbit endotoxemia model^[2].
Dosage:	1 μg/kg/min
Administration:	Left jugular vein infusion for 12 min
Result:	Decreased mesenteric blood flow (MBF) and increased mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits.

Clinical Trial

分子量

1048.28

Formula

C₄₆H₇₃N₁₃O₁₁S₂

CAS 号

876296-47-8

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

细胞实验：

DMSO 中的溶解度 : ≥ 100 mg/mL (95.39 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.9539 mL	4.7697 mL	9.5394 mL
5 mM	0.1908 mL	0.9539 mL	1.9079 mL
10 mM	0.0954 mL	0.4770 mL	0.9539 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.34%

选择批次：

Data Sheet (607 KB) SDS (252 KB)

COA (296 KB) LCMS (87 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Russell JA, et al. Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients. Crit Care. 2017 Aug 15;21(1):213. [Content Brief]

[2]. Milano SP, et al. Selepressin, a novel selective V1A receptor agonist: Effect on mesenteric flow and gastric mucosa perfusion in the endotoxemic rabbit. Peptides. 2020 Jul;129:170318. [Content Brief]

[3]. Barabutis N, et al. Protective Mechanism of the Selective Vasopressin V1A Receptor Agonist Selepressin against Endothelial Barrier Dysfunction. J Pharmacol Exp Ther. 2020 Nov;375(2):286-295. [Content Brief]

[4]. Maybauer MO, et al. The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med. 2014 Jul;42(7):e525-e533. [Content Brief]

Selepressin 相关分类

Cardiovascular Disease

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9539 mL	4.7697 mL	9.5394 mL	23.8486 mL
	5 mM	0.1908 mL	0.9539 mL	1.9079 mL	4.7697 mL
	10 mM	0.0954 mL	0.4770 mL	0.9539 mL	2.3849 mL
	15 mM	0.0636 mL	0.3180 mL	0.6360 mL	1.5899 mL
	20 mM	0.0477 mL	0.2385 mL	0.4770 mL	1.1924 mL
	25 mM	0.0382 mL	0.1908 mL	0.3816 mL	0.9539 mL
	30 mM	0.0318 mL	0.1590 mL	0.3180 mL	0.7950 mL
	40 mM	0.0238 mL	0.1192 mL	0.2385 mL	0.5962 mL
	50 mM	0.0191 mL	0.0954 mL	0.1908 mL	0.4770 mL
	60 mM	0.0159 mL	0.0795 mL	0.1590 mL	0.3975 mL
	80 mM	0.0119 mL	0.0596 mL	0.1192 mL	0.2981 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Selepressin876296-47-8FE 202158FE202158FE-202158Vasopressin ReceptorEndotoxemiathrombinvasopressorsepsisInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Selepressin (Synonyms: FE 202158)

Customer Review

Other Forms of Selepressin: