2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Sintilimab

Sintilimab  (Synonyms: 信迪利单抗; IBI308)

目录号: HY-P99048 纯度: 98.70%
COA

摩尔计算器

Sintilimab (IBI308) 是一种安全有效的人源的 IgG4 单克隆抗体，与 PD-1 结合，其 KD 值为 74 pM。Sintilimab 阻断 PD-1 与其配体 (PD-L1 和 PL-L2) 的相互作用，从而有助于恢复内源性抗肿瘤 T 细胞反应。Sintilimab 联合益生元抑制肺腺癌小鼠肿瘤体积，调节免疫细胞亚群平衡。Sintilimab 可用于经典霍奇金淋巴瘤、非小细胞肺癌和食管癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

CAS No. : 2072873-06-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2000
In-stock
5 mg ￥5200
In-stock
10 mg ￥8850
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Sintilimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sintilimab (IBI308) is a safe and effectivel humanized IgG4 monoclonal antibody that binds to PD-1 with a KD value of 74 pM. Sintilimab blocks the interaction of PD-1 with its ligands (PD-L1 and PL-L2), consequently helping to restore the endogenous antitumour T-cell response. Sintilimab combined with prebiotics inhibits tumor volume and regulates immune cell subpopulation balance in lung adenocarcinoma mice. Sintilimab can be used for the research of classical Hodgkin's lymphoma, non-small cell lung cancer and oesophageal cancer[1][2][3][4][5].

体外研究
(In Vitro)

Sintilimab (150 ng/μL, 12 小时) 在人外周血单核细胞 (PBMCs) 中显示出高水平的 PD-1 结合能力和优越的 T 细胞激活特性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sintilimab 相关抗体:
体内研究
(In Vivo)

Sintilimab (0.1 mg/kg, 1 mg/kg 和 10 mg/kg，腹腔注射, 单次剂量, 1, 8, 12, 5 天) 在人源化小鼠模型中显示出对 NCI-H292 肿瘤的抗肿瘤作用[2]。
Sintilimab (1 mg/kg, 3 mg/kg 和 10 mg/kg, 皮下注射, 单剂量) 在 NCI-H292 肿瘤携带的 NOG 小鼠中对 PD-1 分子表现出很高的亲和力[2]。
Sintilimab (20 mg/kg, 腹腔注射, 2 天一次，连续 21 天) 联合益生元抑制肺腺癌移植瘤体积，减轻肝、肾损伤[4]。

Sintilimab (10 mg/kg, 静脉注射，单剂量) 在 hPD-1 敲入小鼠中的药代动力学参数[2]

Parameter AUC0-4 (h·μg/mL) AUCinf (h·μg/mL) CL (mL/h) Cmax (μg/mL) T1/2 (h) Vss (mL)
Sintilimab 6597.888 7846.554 0.025 218.519 35.623 1.262

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOG mice reconstituted with human PBMCs[2]
Dosage: 1 mg/kg, 3 mg/kg and 10 mg/kg
Administration: i.p., a single dose at 24 h and 72 h
Result: Dose-dependently showed a higher percentage of PD-1 molecule occupancy compared with MDX-1106 (HY-P9903) and MK-3475 (HY-P9902) in mice.
Animal Model: NCI-H292 tumor-bearing NOG mice[2]
Dosage: 1 mg/kg, 3 mg/kg and 10 mg/kg
Administration: s.c., a single dose at 24 h
Result: Increased PD-1 receptor occupancy in both peripheral and CD3+ tumor-infiltrating T cells (TILs) to more than 90% in NCI-H292 tumor-bearing mice.
Animal Model: NCI-H292 tumors in a humanized xenograft mouse model[2]
Dosage: 0.1 mg/kg, 1 mg/kg and 10 mg/kg
Administration: i.p., a single dose at day 1, 8, 12, 15
Result: Inhibited tumor growth much more effectively and was significantly higher in the ratio of CD8+ to Treg tumor-infiltrating lymphocytes than MDX-1106 (HY-P9903) and MK-3475 (HY-P9902) in mice.
Animal Model: C57BL/6J mice (6-8 weeks old, body mass 20-25 g) with lung adenocarcinoma[4]
Dosage: 20 mg/kg
Administration: i.p., once interval 2 days for 21 days
Result: Significantly decreased the tumor volume, showed blurred cell structure and mildly damaged liver lobules and reduced liver and kidney injury in lung adenocarcinoma mice.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

信迪利； 信迪利单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
纯度 & 产品资料

纯度: 98.70%

COA (264 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Sintilimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sintilimab2072873-06-2IBI308信迪利 信迪利单抗IBI 308IBI-308PD-1/PD-L1PD-1/Programmed death-ligand 1IgG4 monoclonal antibodyPD-1PD-L1PL-L2endogenous antitumour T-cell responseHodgkin's lymphomanon-small cell lung canceroesophageal cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Sintilimab
目录号：
HY-P99048
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z