2. PROTAC Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. PROTACs JAK
  4. SJ1008030

SJ1008030 (compound 8) 是一种 JAK2 PROTAC 选择性地降解 JAK2。SJ1008030 抑制 MHH-CALL-4 细胞系增殖的 IC50 值为 5.4 nM。SJ1008030 可用于白血病的研究。

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SJ1008030 Chemical Structure

SJ1008030 Chemical Structure

CAS No. : 2863634-96-0

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SJ1008030 的其他形式现货产品:

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SJ1008030 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 JAK 亚型特异性产品:

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JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SJ1008030 (compound 8) is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 can be used for the research of leukemia[1].

IC50 & Target

IC50: 32.09 nM (MHH-CALL-4), 33.41 nM (MHH-CALL4-GSPT1-WT), 33.55 nM (MHH-CALL-4-GSPT1-G575N) [1]
体外研究
(In Vitro)

SJ1008030 (compound 8) (72 小时) 在 CRLF2r 细胞系 (MHH-CALL-4) 中显示出活性，IC50 为 5.4 nM[1]。 SJ1008030 (0-4.3 μM; 72 小时) 在 MHH-CALL-4 细胞中以剂量依赖性方式降解 JAK、GSPT1 和 IKZF1[1]。
SJ1008030 (0-10 μM; 24h) 剂量依赖性地降解异种移植骨髓细胞 SJBALL021415 中的 JAK2 和 GSPT1 蛋白，表明对 JAK-STAT 信号通路的抑制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SJ1008030 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: The CRLF2r cell lines MHH–CALL-4, KOPN49, MHH–CALL-2, KOP N75, NALM-6 and 697
Concentration: 0-3 μM
Incubation Time: 72 hours
Result: Showed best activity in MHH–CALL-4 cells with an EC50 value of 5.4 nM.

Western Blot Analysis[1]

Cell Line: MHH–CALL-4 cells
Concentration: 1 nM, 10 nM, 100 nM, 1 μM and 4.3 μM
Incubation Time: 72 hours
Result: Significantly degradated JAK2 in MHH–CALL-4 cells dose-dependently while showed weakly effect to JAK1, JAK3 and GSPT1.

Western Blot Analysis[1]

Cell Line: Xenograft SJBALL021415 bone marrow cells
Concentration: 1, 10, 100, 1000 and 1000 nM
Incubation Time: 24 hours
Result: Near-completely degradated JAK2 in a dose-dependent way while showed no effect on GSPT1.
分子量

873.94

Formula

C42H43N13O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SJ1008030 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJ10080302863634-96-0SJ 1008030SJ-1008030PROTACsJAKJanus kinaseantileukemiCRLF2r ALLMHH–CALL-4JAK-STAT signaling pathwaydegraderInhibitorinhibitorinhibit

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