2. Apoptosis
  3. Bcl-2 Family
  4. SMBA1

SMBA1 是一种有效的 Bax 激动剂，Ki 值为 43.3 nM。SMBA1 增强 Bax 表达。SMBA1 显示出抗肿瘤活性。SMBA1 具有肺癌研究的潜力。

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SMBA1 Chemical Structure

SMBA1 Chemical Structure

CAS No. : 906440-37-7

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SMBA1 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SMBA1 is a potent Bax agonist with a Ki value of 43.3 nM. SMBA1 enhances the Bax expression. SMBA1 shows anti-tumor activity. SMBA1 has the potential for the research of lung cancer[1].

IC50 & Target[1]

Bax

43.3 nM (Ki)

体外研究
(In Vitro)

SMBA1 通过阻断 S184 磷酸化、促进 Bax 插入线粒体膜并形成 Bax 寡聚体来诱导 Bax 的构象变化显示 Bax 激动剂活性[1]。
SMBA1 (0, 0.1, 1, 5, 10 µM; 24 h) 在 A549 细胞中以剂量依赖性方式增强 Bax 表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SMBA1 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0, 0.1, 1, 5, 10 µM
Incubation Time: 24 h
Result: Increased the Bax expression in a dose-dependent manner
体内研究
(In Vivo)

SMBA1 (2、10、40、60 mg/kg；腹腔注射；每天一次，持续 10 天) 在小鼠体内显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old male Nu/Nu mice (A549 lung cancer xenografts)[1]
Dosage: 2, 10, 40, 60 mg/kg
Administration: I.p.; once daily for 10 days
Result: Supressed the tumor volume and increased levels of active caspase 3.
分子量

315.32

Formula

C20H13NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SMBA1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMBA1906440-37-7SMBA 1SMBA-1Bcl-2 FamilyBaxanti-tumorlung cancerA549 cellsInhibitorinhibitorinhibit

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目录号：
HY-101996
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