2. Protein Tyrosine Kinase/RTK
  3. ROS Kinase Anaplastic lymphoma kinase (ALK) TAM Receptor c-Met/HGFR
  4. SMU-B

SMU-B 是口服有效的 ALK (IC50<0.5 nM)、c-ros 致癌基因 1 (ROS1)、c-MET (IC50=1.87 nM) 和 AXL (IC50=28.9 nM) 抑制剂。SMU-B 抑制 MKN45、H1993 和 H441 的增殖，IC50 分别为 0.02 μM、1.58 μM 和 2.82 μM。SMU-B 在小鼠模型中表现出抗肿瘤活性。

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SMU-B Chemical Structure

SMU-B Chemical Structure

CAS No. : 1253286-90-6

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SMU-B 相关抗体

Top Publications Citing Use of Products

查看 TAM Receptor 亚型特异性产品:

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Axl Mer Tyro3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SMU-B is the orally active inhibitor for ALK (IC50<0.5 nM), c-ros oncogene 1 (ROS1), c-MET (IC50=1.87 nM) and AXL (IC50=28.9 nM). SMU-B inhibits the proliferation of MKN45, H1993 and H441 with IC50s of 0.02 μM, 1.58 μM and 2.82 μM, respectively. SMU-B exhibits antitumor efficacy in mouse models[1][2].

IC50 & Target

IC50: <5 nM (ALK); 1.87 nM (c-MET); 28.9 nM (AXL)
分子量

515.41

Formula

C26H25Cl2FN4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SMU-B 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMU-B1253286-90-6ROS KinaseAnaplastic lymphoma kinase (ALK)TAM Receptorc-Met/HGFRAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Tyro3AxlMernon small cell lung cancerNSCLCGTL-16MKN45H1993H441U87MGBALB/c mouseInhibitorinhibitorinhibit

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