2. Metabolic Enzyme/Protease
  3. PCSK9
  4. SPC4061

SPC4061 是一种反义核苷酸，是有效的 PCSK9 抑制剂。SPC4061 靶向 PCSK9 的锁定核酸 (LNA)，可用于高胆固醇血症和相关疾病的研究。

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DNA, d(P-thio)((2′-O,4′-C-methylene)rG-(2′-O,4′-C-methylene)m5rU-C-T-G-T-G-G-A-A-(2′-O,4′-C-methylene)rG-(2′-O,4′-C-methylene)m5rC-(2′-O,4′-C-methylene)rG)

SPC4061 Chemical Structure

CAS No. : 1018108-22-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Customer Review

Other Forms of SPC4061:

SPC4061 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases[1][2].

体外研究
(In Vitro)

SPC4061 reduces PCSK9 mRNA levels in treated cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SPC4061 相关抗体:
体内研究
(In Vivo)

SPC4061 (20 mg/kg first s.c.; and 5 mg/kg at day 7-28, once weekly for 4 weeks) produces a significant reduction in serum PCSK9 protein levels in monkey models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SPC4061 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPC40611018108-22-9SPC 4061SPC-4061PCSK9Proprotein convertase subtilisin/kexin type 9Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-148689
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