2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. Sphingolactone-24

Sphingolactone-24  (Synonyms: Sph-24)

目录号: HY-136994
产品使用指南

摩尔计算器

Sphingolactone-24 (Sph-24) 是一种选择性、不可逆的中性鞘磷脂酶 (neutral sphingomyelinase (nSMase)) 抑制剂。Sphingolactone-24 具有用于研究急性肺损伤的潜力。

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Sphingolactone-24 Chemical Structure

Sphingolactone-24 Chemical Structure

CAS No. : 881177-99-7

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Sphingolactone-24 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sphingolactone-24 (Sph-24) is a selective and irreversible neutral sphingomyelinase (nSMase) inhibitor. Sphingolactone-24 has the potential for the research of acute lung injury[1].

体外研究
(In Vitro)

Sphingolactone-24 (50 µM; 30 min+24 h) 可抑制 LPS 诱导的 p38 MAPK 磷酸化并拮抗 LPS (HY-D1056) 的抗凋亡作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sphingolactone-24 相关抗体:

Western Blot Analysis[1]

Cell Line: human neutrophils
Concentration: 50 µM
Incubation Time: 30 min +24 h (30 min before LPS (500 ng/ml) treatment)
Result: Inhibited LPS-induced p38 MAPK phosphorylation and antagonized the antiapoptotic effect of LPS.
体内研究
(In Vivo)

Sphingolactone-24 (1 mg/kg; i.p.; 3 and 9 h thereafter LPS) 可减轻 LPS 诱发的 ALI 的严重程度，并提高 LPS 诱发的肺损伤小鼠的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H/HeN breeder mice (LPS 10 mg/kg; intranasal instillation)[1]
Dosage: 1 mg/kg
Administration: I.p.; 3 and 9 h thereafter LPS
Result: Improved survival and reduced the severity of LPS-induced acute lung injury (ALI).
分子量

323.43

Formula

C18H29NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sphingolactone-24 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sphingolactone-24881177-99-7Sph-24Sphingolactone24Sphingolactone 24Sph24Sph 24Phospholipasehuman neutrophilsLPSacute lung injuryp38 MAPKantiapoptoticInhibitorinhibitorinhibit

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