st-Ht31 ammonium 

st-Ht31 ammonium is a membrane-permeable peptide inhibitor of?protein kinase A (PKA) anchoring. st-Ht31 ammonium induces robust cholesterol/phospholipid efflux. st-Ht31 ammonium completely reverses foam cell formation and restores the metabolic health of macrophage^[1][2].

st-Ht31 (5 μM; 2 h) ammonium enhances cholesterol/phospholipid efflux in BHK cells and RAW macrophages^[1].
st-Ht31 (10μM; 24 h) ammonium reverses foam cell formation and restores metabolic health of macrophage^[1].
st-Ht31 (20 μM; 20 min) ammonium abolishes the cAMP inhibition of PMA-induced ERK1/2 activation n HEK293T cells^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2798.32 (free base)

C₁₂₉H₂₁₇N₂₉O₃₉.xNH₃

固体

White to off-white

{N-Stearate}-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr

{N-Stearate}-DLIEEAASRIVDAVIEQVKAAGAY

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Ma L, et al. Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem. 2011 Feb 4;286(5):3370-8.  [Content Brief]

  [2]. Rahamim Ben-Navi L, et al. A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa. Sci Rep. 2016 Nov 30;6:37922.  [Content Brief]