2. Autophagy
  3. Autophagy
  4. STL001

STL001 是一种强效且选择性的 FOXM1 抑制剂。STL001 诱导核 FOXM1 易位至细胞质并促进其自噬降解。STL001 使人类癌症对广谱癌症疗法敏感。

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STL001 Chemical Structure

STL001 Chemical Structure

CAS No. : 3047493-70-6

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STL001 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STL001 is potent and selective FOXM1 inhibitor. STL001 induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation. STL001 sensitizes human cancers to a broad-spectrum of cancer therapies[1].

体外研究
(In Vitro)

STL001 (1-10 μM; 24 h) 导致细胞 FOXM1 蛋白水平剂量依赖性降低[1]。
STL001 (5 μM; 24 h) 诱导核 FOXM1 易位至细胞质并促进其自噬降解[1]。 U2OS-C3-luc cells 5 μM 24 h Resulted in reduced FOXM1 levels with increased expression of autophagy marker protein LC3.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STL001 相关抗体:

Western Blot Analysis[1]

Cell Line: OVCAR-8, ES-2, HCT-116, HCT-FET, FLO-1, TAM-R, HCC-1143, 22Rv1, LNCaP
Concentration: 1 μM, 5 μM, and 10 μM
Incubation Time: 24 h
Result: Significantly reduced the cellular levels of FOXM1 protein.

Western Blot Analysis[1]

Cell Line: U2OS-C3-luc cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Resulted in reduced FOXM1 levels with increased expression of autophagy marker protein LC3.
分子量

509.52

Formula

C27H23N7O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STL001 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STL0013047493-70-6STL 001STL-001AutophagyFOXM1 inhibitorautophagic degradationLC3Inhibitorinhibitorinhibit

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HY-158420
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