2. Metabolic Enzyme/Protease
  3. Thrombin
  4. Sulodexide

Sulodexide 是口服有效的糖胺聚糖混合物，由低分子量肝素 (80%) 和硫酸皮肤素 (20%) 组成。Sulodexide 通过与抗凝血酶 III (AT III) 和肝素辅因子 II (HC II) 相互作用并抑制凝血酶形成而表现出抗血栓活性。Sulodexide 通过释放组织纤溶酶原激活剂 (tPA) 发挥促纤溶活性。Sulodexide 具有内皮保护和抗炎作用，可改善慢性静脉疾病。

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Sulodexide Chemical Structure

Sulodexide Chemical Structure

CAS No. : 57821-29-1

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Sulodexide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sulodexide is an orally active mixture of glycosaminoglycans composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease[1].

体外研究
(In Vitro)

Sulodexide (0–200 μg/mL, 24 小时) 促进小鼠系膜细胞中纤连蛋白和 III 型胶原的合成[2]。
Sulodexide (50 µg/mL, 48 小时) 显著抑制肝窦内皮细胞中毛细血管化标志物的表达[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sulodexide 相关抗体:

Western Blot Analysis[2]

Cell Line: Mouse mesangial cells (diabetic nephropathy)
Concentration: 0–200 μg/mL
Incubation Time: 24 hours
Result: Increased synthesis of fibronectin and collagen type III in cells, further enhanced under high glucose conditions.

Real Time qPCR[4]

Cell Line: Mouse liver sinusoidal endothelial cells (LSECs; liver fibrosis)
Concentration: 50 µg/mL
Incubation Time: 48 hours
Result: Significantly reduced expression of capillarization markers Edn1 and CD34.
体内研究
(In Vivo)

Sulodexide (1 mg/kg, 每日一次, 口服, 持续 12 周) 显著改善了 Streptozotocin (HY-13753) 诱导的 I 型糖尿病肾病小鼠的蛋白尿和肾功能[2]。
Sulodexide (5 mg/kg 和 15 mg/kg, 每日一次, 腹腔注射, 持续 5 天) 在氧诱导的视网膜病 ICR 小鼠模型中显著抑制了视网膜新生血管的形成并抑制了促血管生成蛋白的表达[3]。
Sulodexide (20 mg/kg, 每日一次, 胃内灌胃, 持续 4 周) 显著减轻了 Thioacetamide (HY-Y0698) 诱导的肝纤维化小鼠模型中的纤维化程度[4]。
Sulodexide (40 mg/kg, 胃内给药, 单次给药) 显著提高了 LPS (HY-D1056) 诱导的内毒素血症 C57BL/6J 小鼠模型的存活率并减轻了肺损伤[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Streptozotocin (HY-13753)-induced type I diabetic nephropathy in C57BL/6 mice model[2]
Dosage: 1 mg/kg
Administration: Oral gavage (p.o.), once daily for 12 weeks
Result: Significantly reduced urinary albumin levels, improved renal function, increased GBM perlecan expression, reduced collagen I and IV deposition, and ERK activation.
Animal Model: Oxygen-induced retinopathy (OIR) model in ICR mice[3]
Dosage: 5 mg/kg and 15 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 5 days
Result: Significantly reduced avascular area, decreased neovascular tufts and lumens.
Significantly inhibited expression of MMP-2, MMP-9, and VEGF
Animal Model: Thioacetamide (HY-Y0698)-induced liver fibrosis in C57BL/6 mice model[4]
Dosage: 20 mg/kg
Administration: Intragastric administration (i.g.), once daily for 4 weeks
Result: Significantly reduced expression of fibrosis markers (Col1a1 and α-SMA), decreased hydroxyproline levels, and inhibited ECM deposition in liver tissue.
Animal Model: LPS (HY-D1056)-induced endotoxemia in C57BL/6J mice model[5]
Dosage: 40 mg/kg
Administration: Intragastric administration (i.g.), single dose
Result: Significantly reduced plasma Syndecan-1 (SDC1) levels, increased survival rate, reduced lung injury, and restored endothelial glycocalyx damage.
CAS 号
性状

固液混合物

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

COA (262 KB)

产品使用指南 (1538 KB)
参考文献

Sulodexide 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulodexide57821-29-1Thrombinantithromboticprofibrinolyticischemiareperfusion injuryacute peritonitisintermittent claudicationperipheral arterial occlusive diseasepost-myocardial infarction,Inhibitorinhibitorinhibit

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