2. Protein Tyrosine Kinase/RTK
  3. DYRK
  4. tBID

tBID 是同源结构域相互作用蛋白激酶2 (HIPK2) 的选择性抑制剂，IC50值为 0.33 μM。

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tBID Chemical Structure

tBID Chemical Structure

CAS No. : 1639895-85-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3315
In-stock
1 mg ￥1100
In-stock
5 mg ￥2850
In-stock
10 mg ￥3990
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

tBID 相关抗体

Top Publications Citing Use of Products

查看 DYRK 亚型特异性产品:

查看所有亚型
DYRK1 DYRK2 DYRK3 DYRK4

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) with an IC50 of  0.33 µM.

IC50 & Target

IC50: 0.33 µM (HIPK2)[1]
体外研究
(In Vitro)

Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival. TBID, displays toward HIPK2 unprecedented efficacy (IC50=0.33 µM) and selectivity (Gini coefficient 0.592 out of a panel of 76 kinases). The two other members of the HIPK family, HIPK1 and HIPK3, are also inhibited by TBID albeit less efficiently than HIPK2. The mode of action of TBID is competitive with respect to ATP, consistent with modelling. TBID interacts with the hinge region through hydrophobic interactions between Val 213, Val 261, Phe 277, Leu 280, Met 331, Ile 345, and the tetrabromine moiety, while the symmetric nitrogen atom at position 3 interacts with the catalytic Lys 228, thus playing a crucial role in the binding architecture[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

tBID 相关抗体:
分子量

528.78

Formula

C11H3Br4N3O2
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 20 mg/mL (37.82 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8911 mL 9.4557 mL 18.9115 mL
5 mM 0.3782 mL 1.8911 mL 3.7823 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.03%

COA (175 KB) HNMR (441 KB) LCMS (131 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

HepG2 cells (human hepatocellular carcinoma) are cultured in Dulbecco's modified Eagle's medium supplemented with 10% fetal calf serum, 2 mM L-glutamine, 100 unit/mL penicillin and 100 µg/mL streptomycin. Treatments with TBID are performed in the same medium but with 1% fetal calf serum; control cells are treated with the solvent (DMSO). Cell viability is evaluated by means of MTT[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

tBID 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8911 mL 9.4557 mL 18.9115 mL 47.2786 mL
5 mM 0.3782 mL 1.8911 mL 3.7823 mL 9.4557 mL
10 mM 0.1891 mL 0.9456 mL 1.8911 mL 4.7279 mL
15 mM 0.1261 mL 0.6304 mL 1.2608 mL 3.1519 mL
20 mM 0.0946 mL 0.4728 mL 0.9456 mL 2.3639 mL
25 mM 0.0756 mL 0.3782 mL 0.7565 mL 1.8911 mL
30 mM 0.0630 mL 0.3152 mL 0.6304 mL 1.5760 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

tBID1639895-85-4DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-100464
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