1. Anti-infection
  2. Antibiotic HIV SARS-CoV
  3. Teicoplanin sodium

Teicoplanin sodium  (Synonyms: Antibiotic MDL-507 sodium; MDL-507 sodium)

目录号: HY-A0097A
产品使用指南

Teicoplanin sodium 是一种糖肽抗生素, 可用于革兰氏阳性菌引起的严重感染的相关研究, 包括耐 Methicillin 的金黄色葡萄球菌和肠球菌。Teicoplanin sodium 对 HIV-1、SARS-CoV1 和 SARS-CoV2 显示出抗病毒活性。Teicoplanin sodium 具有抗 MRSA 活性。

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Teicoplanin sodium Chemical Structure

Teicoplanin sodium Chemical Structure

CAS No. : 184539-13-7

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Teicoplanin sodium 的其他形式现货产品:

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity[1][2].

IC50 & Target

Glycopeptide

 

体外研究
(In Vitro)

Teicoplanin sodium 显示出抗病毒活性,对 HEK293T 细胞中的 HIV-luc/SARS-CoV-S 病毒、A549 细胞中的 2019-nCoV-Spike-病毒和Vero E6 细胞中的 SARS-CoV-2 病毒的 IC50 值分别为 0.39、1.66、15.7 µM[1]
Teicoplanin sodium 可抑制人 CEM 细胞培养物中的 HIV-1 病毒,EC50 值为 17 µM[1]
其机制是通过 Teicoplanin sodium 亲脂部分与酶的相互作用抑制抑制组织蛋白酶 L 活性并阻止 SARS-CoV 从晚期内体释放[1]
Teicoplanin sodium 表现出抗 MRSA 活性,对 MRSA ATCC 43300 的 MIC 值为 0.5 mg/L[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Teicoplanin sodium (10, 30 mg/kg; i.v.) 在小鼠 MRSA 大腿感染模型中表现出剂量依赖性的总细菌密度下降[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20-30 g, Male CD1 mice (2 * 106 cfu/mL MRSA (43 300) 50 µL; murine thigh infection model)[2]
Dosage: 10, 30 mg/kg
Administration: I.v.; once every 12 h
Result: Showed a dose-dependent decline in the total bacterial density with the total bactericidal effect was achieved with dosages of ≥10 mg/kg/day and suppression of resistance with dosages ≥30 mg/kg/day.
Clinical Trial
分子量

1564.3-1907.7

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Teicoplanin sodium
目录号:
HY-A0097A
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