2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. iGluR GABA Receptor Sodium Channel Calcium Channel Potassium Channel Carbonic Anhydrase
  4. Topiramate D12

Topiramate D12  (Synonyms: 托吡酯-D12; McN 4853 D12 ; RWJ 17021 D12)

目录号: HY-110234
COA 产品使用指南

摩尔计算器

Topiramate D12 (McN 4853 D12) 是Topiramate 的氘代物。Topiramate 是一种广谱抗癫痫药。Topiramate 也是一种 GluR5 受体拮抗剂，可通过增强 GABAergic 活性，抑制 kainate/AMPA 受体，抑制钠和钙通道的电压敏感，增加钾电导并抑制 carbonic anhydrase 来产生抗癫痫作用。

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Topiramate D12 Chemical Structure

Topiramate D12 Chemical Structure

CAS No. : 1279037-95-4

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规格 价格 是否有货
1 mg ￥3400
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Other Forms of Topiramate D12:

Topiramate D12 相关抗体

Top Publications Citing Use of Products

查看 iGluR 亚型特异性产品:

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AMPA Receptor NMDA Receptor Kainate Receptor

查看 Sodium Channel 亚型特异性产品:

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Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

查看 Carbonic Anhydrase 亚型特异性产品:

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CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3].

IC50 & Target

Kainate Receptor

 

分子量

351.44

Formula

C12H9D12NO8S
CAS 号
非标记 CAS

97240-79-4
性状

固体

颜色

White to off-white

中文名称

托吡酯-d12
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.90%

COA (295 KB)

产品使用指南 (1538 KB)
参考文献

Topiramate D12 相关分类

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Keywords:

Topiramate D121279037-95-4McN 4853 D12 RWJ 17021 D12托吡酯-d12Topiramate D 12Topiramate D-12iGluRGABA ReceptorSodium ChannelCalcium ChannelPotassium ChannelCarbonic AnhydraseIonotropic glutamate receptorsGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorNa channelsNa+ channelsCa2+ channelsCa channelsKcsACarbonate dehydrataseDeuteriumlabeledGluR5GABAergickainiteAMPAvoltage-sensitiveantiepilepticInhibitorinhibitorinhibit

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目录号：
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