2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. TPMPA

TPMPA 是异四氢烟酸和 3-APMPA 的混合物，是 GABAC 的第一个选择性拮抗剂 (KB = 2.1 μM)，但不与 GABAA (KB = 320 μM) 或 GABAB (EC50 = 500 μM) 受体相互作用。TPMPA 具有抑制神经节细胞定向选择性的潜力。

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TPMPA Chemical Structure

TPMPA Chemical Structure

CAS No. : 182485-36-5

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规格 价格 是否有货 数量
10 mg ￥6174
3 - 4 周
50 mg   询价  
100 mg   询价  

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Customer Review

TPMPA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells[1][2][3].

IC50 & Target

KB: 2.1 μM (GABAC)
体外研究
(In Vitro)

TPMPA antagonizes the GABA currents of ρ1 receptors (IC50 = 1.6 μM) and those of the chimeric ρ1/α1 receptors with approximately the same potency (IC50 = 1.3 μM)[1].
TPMPA shows weak activity against rho-1 and rho-2 receptors, with the KB values of 2.0 and 15.6 μM, respectively[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TPMPA 相关抗体:
分子量

161.14

Formula

C6H12NO2P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TPMPA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPMPA182485-36-5GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorisoguvacine3-APMPAganglionρ1/α1rho-1rho-2Inhibitorinhibitorinhibit

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产品名称：
TPMPA
目录号：
HY-101359
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