2. Apoptosis Protein Tyrosine Kinase/RTK JAK/STAT Signaling Metabolic Enzyme/Protease
  3. Ferroptosis EGFR TrxR Apoptosis
  4. TrxR/EGFR-IN-1

TrxR/EGFR-IN-1 (Compound L1Au2) 是一种 TrxR/EGFR 抑制剂。TrxR/EGFR-IN-1 对吉非替尼 (HY-50895) 敏感和耐药的肺癌均具有活性，能有效抑制肿瘤增殖，促进细胞凋亡 (apoptosis)。TrxR/EGFR-IN-1 通过自噬溶酶体和蛋白酶体途径促进 GPX4 蛋白降解，导致铁死亡 (ferroptosis)。此外，TrxR/EGFR-IN-1 还能诱导内质网应激并触发免疫原性细胞死亡。TrxR/EGFR-IN-1 可用于吉非替尼 (HY-50895) 耐药肺癌的研究。

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TrxR/EGFR-IN-1 Chemical Structure

TrxR/EGFR-IN-1 Chemical Structure

CAS No. : 3038386-42-1

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TrxR/EGFR-IN-1 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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TrxR1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor. TrxR/EGFR-IN-1 is active against both Gefitinib (HY-50895)-sensitive and resistant lung cancers, effectively inhibiting tumor proliferation and promoting apoptosis. TrxR/EGFR-IN-1 promotes the degradation of GPX4 protein through autophagolysosomal and proteasomal pathways, leading to ferroptosis. In addition, TrxR/EGFR-IN-1 can induce endoplasmic reticulum stress and trigger immunogenic cell death. TrxR/EGFR-IN-1 can be used for the research of Gefitinib (HY-50895)-resistant lung cancer[1].

分子量

710.88

Formula

C24H24AuClFN6O2P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TrxR/EGFR-IN-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TrxR/EGFR-IN-13038386-42-1FerroptosisEGFRTrxRApoptosisEpidermal growth factor receptorErbB-1HER1Thioredoxin ReductasePC9 cellsPC9GR cellsH1975 cellsBeas-2b cellsLung cancer modelInhibitorinhibitorinhibit

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