2. GPCR/G Protein
  3. LPL Receptor
  4. Udifitimod

Udifitimod  (Synonyms: BMS-986166)

目录号: HY-119245
产品使用指南

摩尔计算器

Udifitimod (BMS-986166) 是一种有效的、选择性的和具有口服活性的 S1P1R 调节剂。Udifitimod 具有研究自身免疫性疾病的潜力。

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Udifitimod Chemical Structure

Udifitimod Chemical Structure

CAS No. : 1883345-06-9

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规格 是否有货
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Customer Review

Udifitimod 相关抗体

Top Publications Citing Use of Products

查看 LPL Receptor 亚型特异性产品:

查看所有亚型
LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Udifitimod (BMS-986166) is a potent, selective and orally active S1P1R modulator. Udifitimod has the potential for the research of autoimmune diseases[1][2].

IC50 & Target[1]

S1PR1

 

体内研究
(In Vivo)

Udifitimod (0.1, 0.5 mg/kg; p.o.; once daily for 21 days) 在自身免疫性脑脊髓炎模型中显示出抗炎活性[1]。
Udifitimod (0.1, 0.5 mg/kg; p.o.; once daily for 50 days) 降低了胶原诱导性关节炎 (CIA) 模型的临床评分和足爪组织学评分[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, C57BL/6 female mice (autoimmune encephalomyelitis model (EAE))[2]
Dosage: 0.1, 0.5 mg/kg
Administration: P.o.; once daily for 21 days
Result: Showed a dose-dependent reduction in clinical scores for inflammation.
Animal Model: DBA/1 mice (collagen-induced arthritis (CIA) model)[2]
Dosage: 0.1, 0.5 mg/kg
Administration: P.o.; once daily for 50 days
Result: Dose dependently reduced both the clinical score as well as the paw histology score following the dosing regimens.
分子量

379.54

Formula

C25H33NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Udifitimod 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Udifitimod1883345-06-9BMS-986166BMS986166BMS 986166LPL ReceptorLysophospholipid Receptororally activeautoimmuneCIAInhibitorinhibitorinhibit

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