1. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  2. Phosphodiesterase (PDE) Adrenergic Receptor
  3. UK-1745

UK-1745 是一种具有血管扩张和抗心律失常特性的强心剂。UK-1745 通过抑制磷酸二酯酶III (phosphodiesterase III) 来增加心肌细胞内的环磷酸腺苷 (cAMP) 水平,从而增强心肌收缩力。此外,UK-1745 还具有 β-肾上腺素受体 (adrenergic receptor) 阻断活性,有助于减少心脏的耗氧量并避免钙离子过载。这些特性使 UK-1745 拥有研究充血性心力衰竭的潜力。

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UK-1745 Chemical Structure

UK-1745 Chemical Structure

CAS No. : 170684-14-7

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UK-1745 is a cardiotonic agent with vasodilating and antiarrhythmic properties. It increases intracellular levels of cyclic adenosine monophosphate (cAMP) in cardiomyocytes by inhibiting phosphodiesterase III, thereby enhancing myocardial contractility. Additionally, UK-1745 exhibits β-adrenergic receptor blocking activity, which helps reduce the oxygen consumption of the heart and prevent calcium overload. These characteristics make UK-1745 a promising candidate for research in congestive heart failure[1][2].

分子量

310.82

Formula

C16H23ClN2O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
UK-1745
目录号:
HY-117181
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