2. Anti-infection
  3. Antibiotic Bacterial
  4. Valnemulin

Valnemulin 是一种口服有效的广谱抗生素，对革兰氏阴性菌和革兰氏阳性菌、厌氧菌、支原体和螺旋体有抗菌作用。Valnemulin 可改善猪肠道疾病、急性多关节炎和地方性肺炎。Valnemulin 对脂多糖 (HY-D1056) 诱导的肺损伤具有抗炎活性。

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Valnemulin Chemical Structure

Valnemulin Chemical Structure

CAS No. : 101312-92-9

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Valnemulin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Valnemulin is an orally active broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, anaerobic bacteria, Mycoplasma, and Spirochetes. Valnemulin ameliorates enteric diseases, acute polyarthritis and enzootic pneumonia in pigs[1]. Valnemulin exhibits anti-inflammatory efficacy against lipopolysaccharide (HY-D1056)-induced lung injury[2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero IC50
14.9 μg/mL
Compound: Valnemulin
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
[PMID: 28291943]
Vero IC50
15 μg/mL
Compound: Valnemulin
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 30145051]
体外研究
(In Vitro)

Valnemulin 对 Mycoplasma hyopneumoniae 和 Mycoplasma hyosynoviae 具有抗菌活性，MIC90 分别为 0.0005 μg/mL 和 0.0001 到 0.00025 μg/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Valnemulin 相关抗体:
体内研究
(In Vivo)

Valnemulin (100 mg/kg，灌胃，单剂量) 对 LPS 诱导的 BALB/c 小鼠急性肺损伤具有肺保护作用[2]。
Valnemulin (10 mg/kg，口服，10 天) 在实验性牛支原体感染犊牛模型中具有控制效果，能有效地消除肺中的牛分枝杆菌[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lipopolysaccharide induced acute lung injury in BALB/c mice[2].
Dosage: 100 mg/kg
Administration: i.g., single dose
Result: Reduced levels of neutrophils, lymphocytes and macrophages, and expressions of TNF-α, IL-6, and IL-1β in bronchoalveolar lavage fluid (BALF).
Increased superoxidase dismutase (SOD) activity in BALF, decreased myeloperoxidase (MAO) activity in lung.
Animal Model: Mycoplasma bovis infection treated male calves aged 10-35 days[3]
Dosage: 10 mg/kg
Administration: p.o., 10 days
Result: Resulted in a rapid diminution of clinical signs, restoration of appetite and reversal of weight loss.
Effectively reduced the isolation of Pasteurella multocida from the calves, lungs.
分子量

564.82

Formula

C31H52N2O5S
CAS 号
结构分类
初始来源

pig
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Valnemulin 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valnemulin101312-92-9AntibioticBacterialMycoplasma hyopneumoniaeMycoplasma hyosynoviaeBALB/c miceacute lung injuryInhibitorinhibitorinhibit

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