2. Apoptosis Anti-infection Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Apoptosis Arenavirus Fungal Antibiotic Reactive Oxygen Species
  4. Verrucarin J

Verrucarin J  (Synonyms: Muconomycin B)

目录号: HY-N10113 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

Verrucarin J (Muconomycin B) 是 Myrothecium 真菌家族的代谢物。Verrucarin J 诱导活性氧 (ROS) 生成和癌细胞系凋亡 (apoptosis)，例如 A549、HCT 116 和 SW-620 细胞。Verrucarin J 具有抗 Candida albicans 和 Mucor miehei 的活性。Verrucarin J 抑制沙粒病毒 Junin (JUNV) 产量，IC50 为 1.2 ng/mL。

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Verrucarin J Chemical Structure

Verrucarin J Chemical Structure

CAS No. : 4643-58-7

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1 mg ￥6000
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Verrucarin J 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC50 of 1.2 ng/mL[1][2][3][4][5].

体外研究
(In Vitro)

Verrucarin J (0, 5, 10, 20, 50 nM; 24 hours) induces the apoptosis of A549 cells[1].
Verrucarin J (0, 1, 2, 5, 10, 20, 50 nM; 24, 48, 72 hours) significantly inhibits cell proliferation of A549 and H1793 cells with IC50 values of approximately 10 nM and 20 nM after 48 h of treatment, respectively[1].
Verrucarin J (0, 0.1, 0.2, 0.3, 0.4, 0.5 μM; 24 hours) has an IC50 of 300 nM for HCT 116 and SW-620 cell proliferation[2].
Verrucarin J (0, 10, 20 nM, 48 hours) inhibits cancer stem cell (CSC) self-renewal pathways Wnt1/β-catenin and Notch1 and down-regulates the expression of key CSC specific genes (ALDH1, LGR5, OCT4 and CD133) of A549 cells[1].
Verrucarin J (compound 2; 50 μg/disk) shows noteworthy activities against Candida albicans and Mucor miehei[3].
Verrucarin J reduces JUNV yield more than 2 log units and has a similar effect against the arenavirus Tacaribe[4].
Verrucarin J reduces the cell viability of Vero cells with a cytotoxic concentration 50% (CC50) of 8.2 ng/mL[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Verrucarin J 相关抗体:
体内研究
(In Vivo)

Verrucarin J (0.5 mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model[2].
Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug and suppresses tumor growth and metastasis[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks old BALB/c athymic nude mice (nu/nu) with pCMV/HCT 116 and AKT/HCT 116 xenografts[2]
Dosage: 0.5 mg/kg body weight
Administration: i.p. for 4 weeks
Result: Reduced the expression of prosurvival markers pAKT, Notch1, p65, and Ki67 in all tumors.
Animal Model: Female nude nu/nu (5 to 6 weeks old) mice with A2780 xenografts[5]
Dosage: 0.1, 0.5, 2.0 mg/kg (vehicle: 10% DMSO, 90% glyceryl trioctanoate)
Administration: i.p. for three weeks after 10 days of injection of A2780 cells
Result: Reduced tumor weight (32% lower compared to control), and reduced visible metastasis in 0.1 mg/kg.
Showed a significant reduction in visible peritoneal tumors (61% lower compared to control group) and highly reduced visible metastasis in 0.5 mg/kg.
Reduced ovarian tumor weight by 71% compared to vehicle in 0.5 mg/kg.
In lethal dose 2 mg/kg, mice sick with a swollen belly, body fluid and subsequently died within 3 treatments.
分子量

484.54

Formula

C27H32O8
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

Myrothecium fungus family, Stachybotrys chartarum
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (276 KB)

产品使用指南 (1538 KB)
参考文献

Verrucarin J 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Verrucarin J4643-58-7Muconomycin BApoptosisArenavirusFungalAntibioticReactive Oxygen Speciesarenavirus JuninCandida albicansMucor mieheiHCT 116 cellsSW-620 cellsA549 cellsInhibitorinhibitorinhibit

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