2. GPCR/G Protein
  3. Oxytocin Receptor
  4. WAY-267464

WAY-267464 是非肽催产素受体 (OTR) 激动剂。WAY-267464 通过抗利尿激素 1A 受体拮抗剂作用损害大鼠的社会认知。WAY-267464 可用于精神障碍的研究，如自闭症谱系障碍、精神分裂症和社交焦虑障碍。(OTR)

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WAY-267464 Chemical Structure

WAY-267464 Chemical Structure

CAS No. : 847375-16-0

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WAY-267464 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder[1].

体内研究
(In Vivo)

WAY-267464 (i.p., 100 mg/kg) has antagonism of the memory-enhancing effects of AVP (0.005 mg/kg) on social recognition at a retention interval of 120 min[1].
WAY-267464 (i.p., 10 and 30 mg/kg) has the antagonist effects on the arginine vasopressin Vasopressin (HY-P0049) (AVP)-induced (0.005 mg/kg) facilitation of social recognition at a retention interval of 120 min[1].
WAY-267464 (i.p., 30 and 100 mg/kg, given alone) impairs memory at a 30 min retention interval[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar Rats (adult: 9-10 weeks; juvenile: 3-4 weeks)[1]
Dosage: 1, 10, 30, and 100 mg/kg
Administration: Intraperitoneal; 1, 10, 30, and 100 mg/kg
Result: Completely prevented the AVP-induced preference for the novel over the familiar juvenile stimulus rats.
Prevented the increase in preference for the novel over the familiar juvenile stimulus rat induced by AVP at 10 and 30 mg/kg, but not 1 mg/kg.
分子量

581.66

Formula

C32H35N7O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WAY-267464 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WAY-267464847375-16-0WAY267464WAY 267464Oxytocin ReceptorOXTRoxytocin receptor (OTR)social recognition memoryvasopressin 1A receptorOxytocinVasopressinpsychiatric disordersautism spectrum disorderschizophreniasocial anxiety disorderInhibitorinhibitorinhibit

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