2. PROTAC Apoptosis Epigenetics
  3. PROTACs Apoptosis METTL3
  4. WD6305

WD6305 是一种有效的和选择性的 METTL3-METTL14 PROTAC 降解剂，对 METTL3 和 METTL14 的 DC50 分别为 140 nM 和 194 nM。WD6305 可以抑制 m6A 修饰和急性髓性白血病细胞增殖，并诱导细胞凋亡(apoptosis)。WD6305 具有抗肿瘤的活性。(Pink: UZH2 (HY-115717); Black: Linker; Blue: VHL ligand (HY-150803))

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WD6305 Chemical Structure

WD6305 Chemical Structure

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WD6305 的其他形式现货产品:

Customer Review

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WD6305 相关抗体

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WD6305 is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 inhibits m6A modification and proliferation of AML cells, and induces apoptosis. WD6305 has antitumor activity[1].(Pink: UZH2 (HY-115717); Black: Linker; Blue: VHL ligand (HY-150803))

IC50 & Target

DC50: 140 nM (METTL3); D max: 91.9% (METTL3) [1]
DC50: 194 nM (METTL14)[1]
体外研究
(In Vitro)

WD6305 (20-5000 nM; 24 小时) 在 Mono-Mac-6 细胞中降低 METTL3 蛋白水平，DC50 为 140 nM，D max为 91.9%[1]。
WD6305 (20-5000 nM; 24 小时) 在 Mono-Mac-6 细胞中降低 METTL14 蛋白水平，DC50 为 194 nM[1]。
WD6305 (0.5-10 μM; 48 小时) 在 Mono-Mac-6 细胞中降低 m6A 与 polyA mRNA 的比例，抑制细胞增殖和诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WD6305 相关抗体:

Western Blot Analysis[1]

Cell Line: Mono-Mac-6 cells
Concentration: 20, 50, 100, 250, 500, 1000, 2000 and 5000 nM
Incubation Time: 24 h
Result: Reduced METTL3 and METTL14 protein levels in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: Mono-Mac-6 cells
Concentration: 1 and 2.5 μM
Incubation Time: 48 h
Result: Increased the levels of cleaved caspase-3 and cleaved PARP.
分子量

1112.38

Formula

C61H75F2N11O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WD6305 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WD6305WD 6305WD-6305PROTACsApoptosisMETTL3Methyltransferase-like 3AMLMono-Mac-6 cellsInhibitorinhibitorinhibit

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目录号：
HY-160415
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