2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. NOD-like Receptor (NLR) NF-κB Reactive Oxygen Species
  4. Yadanzigan

Yadanzigan (YDZG) 是一种抗炎剂和 NLRP3 抑制剂。Yadanzigan 通过抑制 NF-κB 通路和活性氧 (Reactive Oxygen Species) 的产生，特异性抑制 NLRP3 的激活。Yadanzigan 对 LPS (HY-D1056) 诱导的小鼠急性肺损伤 (ALI) 有调节作用。

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Yadanzigan Chemical Structure

Yadanzigan Chemical Structure

CAS No. : 76588-87-9

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规格 价格 是否有货 数量
1 mg ￥1584
1 - 2 周
5 mg ￥3960
1 - 2 周
10 mg   询价  
50 mg   询价  

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Yadanzigan 相关抗体

Top Publications Citing Use of Products

查看 NOD-like Receptor (NLR) 亚型特异性产品:

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NLRP3 NLRP1 NOD1 NOD2

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Yadanzigan (YDZG) is an anti-inflammatory agent and a NLRP3 inhibitor. Yadanzigan specifically inhibits NLRP3 activation via inhibiting NF-κB pathway and Reactive Oxygen Species production. Yadanzigan also moderates LPS (HY-D1056)-induced acute lung injury (ALI) in mice[1].

IC50 & Target[1]

NLRP3 inflammasome

 

体外研究
(In Vitro)

Yadanzigan (20, 40, 80 μM; 1 h) 促进 RAW264.7 巨噬细胞的 Nrf2 从细胞质转位到细胞核[1]。
Yadanzigan (20 μM; 1 h) 抑制 LPS 诱导 HEK293T 细胞线粒体活性氧 (ROS) 的生成 (1 μg/mL; 6 h)[1]。
Yadanzigan (40 μM; 1 h) 显著阻断 J774A 细胞在LPS和ATP诱导下 NLRP3 炎性小体的形成[1]。
Yadanzigan (2.5-10 μM 或 10-40 μM; 1, 6, 12 h) 增强J774A.1 和 THP-1 细胞中 TRIM31 表达，促进 NLRP3 蛋白降解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Yadanzigan 相关抗体:

Western Blot Analysis[1]

Cell Line: J774A.1, and THP-1 cells
Concentration: For J774A.1: 2.5 μM, 5 μM, and 10 μM; For THP-1: 10 μM, 20 μM, and 40 μM
Incubation Time: For J774A.1: 6 h, 12 h; For THP-1: 1 hour; 2 h before 1 μg/mL LPS stimulated and another 30 min before 5 mM ATP induced
Result: Led to a sharp decrease in NLRP3 expression in J774A.1 cells.
Led to a large decrease in NLRP3 protein expression in a dose-dependent manner in THP-1 cells.

Immunofluorescence[1]

Cell Line: RAW264.7 macrophages, THP-1 cells
Concentration: 20, 40, and 80 μM
Incubation Time: Pre-treated for 1 h, continue to incubate for 18 h
Result: Decreased caspase-1 p20 activation and mature IL-1β and inhibited cleaved caspase-1 release into supernatants.
体内研究
(In Vivo)

Yadanzigan (5 mg/kg, 10 mg/kg; 静脉注射; 共 3 次) 预防 LPS 诱导的小鼠急性肺损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BABL/C mice (18-22 g)[1]
Dosage: 5 mg/kg, 10 mg/kg
Administration: Intravenous injection; dose at 2 h prior to and 6 h, 12 h after LPS induction
Result: Reduced LPS-induced infiltration of inflammatory cells and cytokine levels, such as TNF-α and IL-6. Inhibited NLRP3 inflammasome activation in lung tissue.
Resulted significantly greater survival rate.
分子量

574.57

Formula

C26H38O14
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Yadanzigan 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Yadanzigan76588-87-9YDZGNOD-like Receptor (NLR)NF-κBReactive Oxygen SpeciesNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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