2. GPCR/G Protein
  3. Vasopressin Receptor
  4. YM218 free base

YM218 free base 是一种具有口服活性的非肽血管加压素 (AVP) 受体拮抗剂。YM218 free base 对大鼠肝脏 V1A 受体具有较高的亲和力，Ki 值为 0.50 nM；对大鼠垂体 V1B、肾脏 V2 和子宫催产素受体的亲和力较低，Ki 值分别为 1510 nM、72.2 nM 和 150 nM。YM218 free base 可用于糖尿病和肾病的研究。

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YM218 free base Chemical Structure

YM218 free base Chemical Structure

CAS No. : 387816-81-1

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YM218 free base 相关抗体

Top Publications Citing Use of Products

查看 Vasopressin Receptor 亚型特异性产品:

查看所有亚型
V1a Receptor  V1b Receptor  V2 Receptor 

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YM218 free base is an orally active non-peptide vasopressin (AVP) receptor antagonist. YM218 free base has a high affinity for rat liver V1A receptors with a Ki value of 0.50 nM; it has a lower affinity for rat pituitary V1B, kidney V2, and uterine oxytocin receptors with Ki values of 1510 nM, 72.2 nM, and 150 nM, respectively. YM218 free base can be used in the study of diabetes and kidney disease[1].

IC50 & Target[1]

Rat liver V1a Receptor

0.5 nM (Ki)

Rat pituitary V1b receptor

1510 nM (Ki)

Rat kidney V2 receptor

72.2 nM (Ki)

分子量

616.70

Formula

C35H38F2N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YM218 free base 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM218387816-81-1YM 218YM-218Vasopressin ReceptorVasopressinantagonistselectiveoxytocindiabetesnephropathyorally activeInhibitorinhibitorinhibit

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产品名称：
YM218 free base
目录号：
HY-118918
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