2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Zenocutuzumab

Zenocutuzumab  (Synonyms: 泽妥珠单抗; MCLA-128; PB4188; R040517)

目录号: HY-P99507 纯度: 99.20%
COA

摩尔计算器

Zenocutuzumab (MCLA-128) 是一种双特异性人源化 IgG1 抗体，包含两个不同的 Fab 臂，靶向 HER2 和 HER3 的细胞外结构域。

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CAS No. : 1969309-56-5

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规格 价格 是否有货 数量
1 mg ￥4800
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Zenocutuzumab 相关抗体

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Bispecific; Humanized

体外研究
(In Vitro)

Zenocutuzumab（0.001-1000 nM；96 小时）抑制肺癌和乳腺癌细胞系的细胞生长[1]。
Zenocutuzumab（0.1-1000 nM；24 小时）抑制 HER3 和 AKT 磷酸化，在肺癌和乳腺癌细胞系中诱导细胞凋亡和细胞周期停滞的标志物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Zenocutuzumab 相关抗体:

Cell Viability Assay[1]

Cell Line: Human bronchiolar epithelial cell lines (HBEC)
Concentration: 0.001 nM, 0.01 nM, 0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM
Incubation Time: 96 h
Result: Reduced the growth of isogenic HBEC expressing either CD74-NRG1 or VAMP2-NRG1 fusions.

Western Blot Analysis[1]

Cell Line: HBEC-CD74-NRG1, LUAD-0061AS3, MDA-MB-175-VII cells
Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM
Incubation Time: 24 hours
Result: Inhibited HER3, STAT3, AKT, p70S6K, and S6 phosphorylation.
体内研究
(In Vivo)

Zenocutuzumab（2.5-25 mg/kg；腹腔注射；每周一次；持续 28 天）导致生长显着减少，包括肿瘤消退[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6 to 12-week-old female NSG™ (LUAD-0061AS3), BALB/c nude (OV-10–0050) or athymic nude (ST2891, ST3204 and CTG-0953) mice injected with NRG1 fusion-positive patient-derived xenograft (PDX) tumors[1].
Dosage: 2.5 mg/kg, 8 mg/kg, or 25 mg/kg
Administration: i.p.; once weekly; for 28 days
Result: Blocked growth of lung and ovarian cancer PDX models.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

泽妥珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human HER3/ERBB3 Protein (ECD, His Tag) can bind Zenocutuzumab. The EC50 for this effect is 107.82 ng/mL.
纯度 & 产品资料
参考文献

Zenocutuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zenocutuzumab1969309-56-5MCLA-128 PB4188 R040517泽妥珠单抗MCLA128MCLA 128PB4188PB 4188PB-4188R040517R 040517R-040517EGFREpidermal growth factor receptorErbB-1HER1HER2HER3humanized IgG1 antibodySTAT3AKTp70S6Kand S6 phosphorylationInhibitorinhibitorinhibit

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