2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. Ziprasidone hydrochloride

Ziprasidone hydrochloride  (Synonyms: 盐酸齐拉西酮; CP-88059 hydrochloride)

目录号: HY-14542A
产品使用指南

摩尔计算器

Ziprasidone (CP-88059) hydrochloride 是一种具有口服活性的 5-HT 和多巴胺 (dopamine) 受体拮抗剂。Ziprasidone hydrochloride 对大鼠 D2 (Ki=4.8 nM)、5-HT2A (Ki=0.42 nM) 和 5-HT1A (Ki=3.4 nM) 有亲和作用。

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Ziprasidone hydrochloride Chemical Structure

Ziprasidone hydrochloride Chemical Structure

CAS No. : 122883-93-6

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Ziprasidone hydrochloride 的其他形式现货产品:

Ziprasidone hydrochloride 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ziprasidone (CP-88059) hydrochloride is an orally active combined 5-HT and dopamine receptor antagonist[1]. Ziprasidone hydrochloride has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM)[1].

IC50 & Target[1] [1] [1][2]

Rat 5-HT2A

0.42 nM (Ki)

Rat 5-HT1A Receptor

3.4 nM (Ki)

Rat D2 Receptor

4.8 nM (Ki)

体外研究
(In Vitro)

Ziprasidone hydrochloride (0-500 nM, 150 seconds) blocks wild-type hERG current[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ziprasidone hydrochloride 相关抗体:

Cell Viability Assay[2]

Cell Line: HEK-293 cells
Concentration: 0-500 nM
Incubation Time: 150 seconds
Result: Blocked wild-type hERG current in a voltage- and concentration-dependent manner (IC50 = 120 nm).
体内研究
(In Vivo)

Ziprasidone hydrochloride (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g[3]
Dosage: 20 mg/kg
Administration: Oral gavage; 20 mg/kg; once daily; 7 weeks
Result: Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P < 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P < 0.001).
Clinical Trial
分子量

449.40

Formula

C21H22Cl2N4OS
CAS 号
中文名称

盐酸齐拉西酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ziprasidone hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ziprasidone122883-93-6CP-88059盐酸齐拉西酮CP88059CP 880595-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorneuronaluptakeantipsychoticSprague-DawleyratsnorepinephrineInhibitorinhibitorinhibit

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