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ZLD10A是一种高效且选择性的EZH2抑制剂,具有抑制H3K27甲基化的活性。ZLD10A能够以纳摩尔级别的效力抑制野生型及突变型EZH2,并对其他10种组蛋白甲基转移酶具有超过1000倍的选择性。ZLD10A在浓度和时间依赖的方式下,抑制了DLBCL细胞系的细胞增殖,展现出潜在的抗增殖效果。ZLD10A可用于 EZH2突变性淋巴瘤的研究。

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ZLD10A Chemical Structure

ZLD10A Chemical Structure

CAS No. : 1782064-91-8

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  • 生物活性

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生物活性

ZLD10A is a highly potent and selective EZH2 inhibitor with the activity of inhibiting H3K27 methylation. ZLD10A can inhibit wild-type and mutant EZH2 with nanomolar potency and has more than 1000-fold selectivity for the other 10 histone methyltransferases. ZLD10A inhibited cell proliferation of DLBCL cell lines in a concentration- and time-dependent manner, showing a potential antiproliferative effect. ZLD10A can be used in the study of EZH2 mutant lymphomas[1].

分子量

612.80

Formula

C37H48N4O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ZLD10A
目录号:
HY-117540
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