2. Anti-infection
  3. Parasite
  4. β-Hederin

β-Hederin 是一种可从 Hedera helix L.(Araliaceae) 分离得到的皂苷，具有抗利什曼虫活性 (antileishmanial)，其在 L. Mexicana promastigotes、L. mexicana amastigotes 和 THP1 细胞中的 IC50 值分别为 1.5 μM、68 nM 和 4.57 μM。

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β-Hederin Chemical Structure

β-Hederin Chemical Structure

CAS No. : 35790-95-5

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5 mg ￥2400
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β-Hederin 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses antileishmanial activity. β-Hederin exhibits IC50 values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
8.4 μM
Compound: 12
Cytotoxicity against human A375 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human A375 cells after 72 hrs by sulforhodamine B assay
[PMID: 23639650]
A549 IC50
15 μM
Compound: 25
Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test
Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test
[PMID: 19200744]
A549 IC50
15.8 μM
Compound: 12
Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay
[PMID: 23639650]
A549 IC50
3 μM
Compound: 25
Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence
Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence
[PMID: 19200744]
DLD-1 IC50
30 μM
Compound: 25
Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test
Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test
[PMID: 19200744]
DLD-1 IC50
4 μM
Compound: 25
Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence
Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence
[PMID: 19200744]
HL-60 IC50
4.4 μg/mL
Compound: 1
Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay
[PMID: 10514313]
HL-60 IC50
9.2 μM
Compound: 12
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 23639650]
L02 IC50
23.07 μM
Compound: B11
Cytotoxicity against human L02 cells by MTT assay
Cytotoxicity against human L02 cells by MTT assay
[PMID: 33964439]
RAW264.7 IC50
1.3 μM
Compound: 6
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay
[PMID: 31301930]
分子量

734.96

Formula

C41H66O11
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥97.0%

COA (270 KB)

产品使用指南 (1538 KB)
参考文献

β-Hederin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Hederin35790-95-5ParasiteInhibitorinhibitorinhibit

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