2. Apoptosis
  3. Apoptosis
  4. 13-Methyltetradecanoic acid

13-Methyltetradecanoic acid  (Synonyms: 13-MTD; 13-Methylmyristic acid)

目录号: HY-131503 纯度: 99.83%
COA 产品使用指南 技术支持

13-Methyltetradecanoic acid (13-MTD)，一种具有强效抗癌作用的饱和支链脂肪酸。13-Methyltetradecanoic acid 在多种类型的人类癌细胞中诱导细胞凋亡 (apoptosis)。

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13-Methyltetradecanoic acid Chemical Structure

13-Methyltetradecanoic acid Chemical Structure

CAS No. : 2485-71-4

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5 mg ￥1600
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10 mg ￥2560
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Other Forms of 13-Methyltetradecanoic acid:

13-Methyltetradecanoic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells[1][2].

体外研究
(In Vitro)

13-Methyltetradecanoic acid (13-MTD; 0-140 μg/mL; 12-24 hours) inhibits cell viability and proliferation in human bladder cancer cells by inducing apoptosis[1].
13-Methyltetradecanoic acid (13-MTD; 70 μg/mL; 2-48 hours) treatments results in significant accumulation of cells with sub-G1 DNA content in a time-dependent manner, with the proportion of sub-G1 phase DNA content ranging from 9.25% to 85.3% over 2-48 hours[1].
13-Methyltetradecanoic acid (13-MTD; 70 μg/mL; 2-24 hours) down-regulates Bcl-2 and up-regulates Bax. This promotes mitochondrial dysfunction, leading to the release of cytochrome c from the mitochondria to the cytoplasm, as well as the proteolytic activation of caspases. 13-Methyltetradecanoic acid down-regulates AKT phosphorylation and activates phosphorylation of p38 and c-Jun N-terminal kinase (JNK)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

13-Methyltetradecanoic acid 相关抗体:

Cell Viability Assay[1]

Cell Line: Bladder cancer cell lines T24, 5637, and UM-UC-3
Concentration: 0 μg/mL, 35 μg/mL, 70 μg/mL, 105 μg/mL, and 140 μg/mL
Incubation Time: 12 hours, 24 hours
Result: Inhibition of cell viability in a dose- and time-dependent manner.

Cell Cycle Analysis[1]

Cell Line: Bladder cancer cell lines T24, 5637, and UM-UC-3
Concentration: 70 μg/mL
Incubation Time: 2 hours, 8 hours, 24 hours, or 48 hours
Result: Resulted in significant accumulation of cells with sub-G1 DNA content in a time-dependent manner.

Western Blot Analysis[1]

Cell Line: T24, 5637, and UM-UC-3 cells
Concentration: 70 μg/mL
Incubation Time: 2 hours, 8 hours, 24 hours
Result: Down-regulated Bcl-2 and up-regulated Bax, and down-regulated AKT phosphorylation and activated phosphorylation of p38 and c-Jun N-terminal kinase (JNK).
体内研究
(In Vivo)

13-Methyltetradecanoic acid (13-MTD; 70 mg/kg/day; oral gavage; daily; for 30 days) significantly suppresses tumor growth in a xenograft model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/C nude mice injected with Jurkat lymphoma cells[2]
Dosage: 70 mg/kg/day
Administration: Oral gavage; daily; for 30 days
Result: Effectively inhibited the growth in vivo in a xenograft model.
分子量

242.40

Formula

C15H30O2
CAS 号
性状

固体

颜色

White to off-white

中文名称

13-甲基十四烷酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

Ethanol 中的溶解度 : ≥ 100 mg/mL (412.54 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.1254 mL 20.6271 mL 41.2541 mL
5 mM 0.8251 mL 4.1254 mL 8.2508 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (10.31 mM); 澄清溶液

    此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

    生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
  • 方案 二

    请依序添加每种溶剂： 10% EtOH    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (10.31 mM); 澄清溶液

    此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

    2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.83%

COA (276 KB) RP-HPLC (238 KB)

产品使用指南 (1538 KB)
参考文献

13-Methyltetradecanoic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 4.1254 mL 20.6271 mL 41.2541 mL 103.1353 mL
5 mM 0.8251 mL 4.1254 mL 8.2508 mL 20.6271 mL
10 mM 0.4125 mL 2.0627 mL 4.1254 mL 10.3135 mL
15 mM 0.2750 mL 1.3751 mL 2.7503 mL 6.8757 mL
20 mM 0.2063 mL 1.0314 mL 2.0627 mL 5.1568 mL
25 mM 0.1650 mL 0.8251 mL 1.6502 mL 4.1254 mL
30 mM 0.1375 mL 0.6876 mL 1.3751 mL 3.4378 mL
40 mM 0.1031 mL 0.5157 mL 1.0314 mL 2.5784 mL
50 mM 0.0825 mL 0.4125 mL 0.8251 mL 2.0627 mL
60 mM 0.0688 mL 0.3438 mL 0.6876 mL 1.7189 mL
80 mM 0.0516 mL 0.2578 mL 0.5157 mL 1.2892 mL
100 mM 0.0413 mL 0.2063 mL 0.4125 mL 1.0314 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

13-Methyltetradecanoic acid2485-71-413-MTD 13-Methylmyristic acid13-甲基十四烷酸ApoptosisBcl-2Baxcytochrome-cp-p38AKTphosphorylationapoptosissaturatedbranched-chainInhibitorinhibitorinhibit

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