2. Anti-infection
  3. Bacterial
  4. 2',4'-Dihydroxylchalcone

2',4'-Dihydroxylchalcone  (Synonyms: 2',4'-DHC)

目录号: HY-W109754
产品使用指南

摩尔计算器

2',4'-Dihydroxychalcone 与 nalidixic acid (HY-B0398) 联用，通过降低膜渗透性对大肠杆菌 (E. coli) 表现出协同作用。

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2',4'-Dihydroxylchalcone Chemical Structure

2',4'-Dihydroxylchalcone Chemical Structure

CAS No. : 1776-30-3

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2',4'-Dihydroxylchalcone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2',4'-Dihydroxychalcone, in combination with nalidixic acid (HY-B0398), exhibits synergistic effects against E. coli by reducing membrane permeability[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 100 μM
Compound: 19
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 21696954]
A549 IC50
23.2 μM
Compound: 8
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 19689125]
A549 IC50
41.6 μM
Compound: 27
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 18440233]
B16-BL6 IC50
> 100 μM
Compound: 8
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
[PMID: 19689125]
B16-BL6 IC50
44.3 μM
Compound: 27
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
[PMID: 18440233]
BJ IC50
262.5 μM
Compound: 3a
Cytotoxicity against human BJ cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
Cytotoxicity against human BJ cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
[PMID: 30482548]
C2C12 IC50
32.26 μg/mL
Compound: 12
Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay
[PMID: 33412152]
HEK293 IC50
109 μM
Compound: 6
Cytotoxicity against human HEK293 cells assessed as cell viability after 24 hrs by cell titer-blue assay
Cytotoxicity against human HEK293 cells assessed as cell viability after 24 hrs by cell titer-blue assay
[PMID: 26473275]
HeLa IC50
23.1 μM
Compound: 27
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 18440233]
HeLa IC50
24.4 μM
Compound: 8
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 19689125]
HL-60 IC50
6.3 μM
Compound: 3
Cytotoxicity against human HL60 cells by MTT assay
Cytotoxicity against human HL60 cells by MTT assay
[PMID: 25091929]
HT-1080 IC50
17 μM
Compound: 8
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
[PMID: 19689125]
HT-1080 IC50
34 μM
Compound: 27
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
[PMID: 18440233]
Lewis lung carcinoma cell line IC50
39.5 μM
Compound: 27
Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay
Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay
[PMID: 18440233]
LoVo IC50
81 μM
Compound: 19
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
[PMID: 21696954]
MCF7 IC50
> 10 μM
Compound: 2d
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 26690274]
MCF7 IC50
> 50 μM
Compound: 3a
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
[PMID: 30482548]
MDA-MB-231 IC50
> 10 μM
Compound: 2d
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 26690274]
NALM-6 IC50
18 μM
Compound: 3
Cytotoxicity against human NALM6 cells by MTT assay
Cytotoxicity against human NALM6 cells by MTT assay
[PMID: 25091929]
PC-3 IC50
> 100 μM
Compound: 19
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
[PMID: 21696954]
PC-3 IC50
13.75 μM
Compound: 3a
Antiproliferative activity against human PC3 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
Antiproliferative activity against human PC3 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
[PMID: 30482548]
Peritoneal macrophage cell CC50
416.7 μM
Compound: DHC
Cytotoxicity against Swiss albino mouse peritoneal macrophages after 24 hrs by MTT assay
Cytotoxicity against Swiss albino mouse peritoneal macrophages after 24 hrs by MTT assay
[PMID: 26169126]
SK-MEL-28 IC50
75 μM
Compound: 19
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay
[PMID: 21696954]
U-373MG ATCC IC50
> 100 μM
Compound: 19
Cytotoxicity against human U373 cells after 72 hrs by MTT assay
Cytotoxicity against human U373 cells after 72 hrs by MTT assay
[PMID: 21696954]
WM-115 IC50
42 μM
Compound: 3
Cytotoxicity against human WM115 cells by MTT assay
Cytotoxicity against human WM115 cells by MTT assay
[PMID: 25091929]
分子量

240.25

Formula

C15H12O3
CAS 号
中文名称

2',4'-二羟查耳酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2',4'-Dihydroxylchalcone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2',4'-Dihydroxylchalcone1776-30-32',4'-DHC2',4'-二羟查耳酮Bacterialnalidixic acidE. colimembrane permeabilityInhibitorinhibitorinhibit

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